Early-life metabolic dysfunction impairs cognition and mitochondrial function in mice

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Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology-
Autor(es): dc.contributorFederal University of Rio de Janeiro, Carlos Chagas Filho Institute of Biophysics, Laboratory of Cardioimunology-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Immunology and Inflammation-
Autor(es): dc.contributorUniversity of Brasilia,Biology Institute, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorFederal University of Rio de Janeiro, Carlos Chagas Filho Institute of Biophysics, Laboratory of Cardioimunology-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolism-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.creatorVilela, Wembley Rodrigues-
Autor(es): dc.creatorBellozi, Paula Maria Quaglio-
Autor(es): dc.creatorPicolo, Victor Luna-
Autor(es): dc.creatorCavadas, Bruna Neves-
Autor(es): dc.creatorMarques, Keila Valentina Silva-
Autor(es): dc.creatorPereira, Louise Tavares Garcia-
Autor(es): dc.creatorGuirao, Ainhoa Rodriguez de Yurre-
Autor(es): dc.creatorAmato, Angélica Amorim-
Autor(es): dc.creatorMagalhães, Kelly Grace-
Autor(es): dc.creatorMortari, Márcia Renata-
Autor(es): dc.creatorMedei, Emiliano Horacio-
Autor(es): dc.creatorGoulart, Jair Trapé-
Autor(es): dc.creatorBem, Andreza Fabro de-
Data de aceite: dc.date.accessioned2024-07-22T11:59:07Z-
Data de disponibilização: dc.date.available2024-07-22T11:59:07Z-
Data de envio: dc.date.issued2024-02-19-
Data de envio: dc.date.issued2024-02-19-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/47780-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.jnutbio.2023.109352-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/793487-
Descrição: dc.descriptionThe impact of overnutrition early in life is not restricted to the onset of cardiovascular and metabolic diseases, but also affects critical brain functions related to cognition. This study aimed to evaluate the relationship between peripheral metabolic and bioenergetic changes induced by a two-hit protocol and their impact on cognitive function in juvenile mice. Three-week-old male C57BL/6 mice received a high-fat diet (HFD) or control diet for 7 weeks, as sociated with two low doses of streptozotocin (STZ) or vehicle. Despite the absence of obesity, HFD+STZ impaired glucose metabolism and induced a trend towards cholesterol increase. The two-hit protocol impaired recognition and spatial memories in juvenile mice, without inducing a depressive-like behavior. HFD+STZ mice presented increased immunoreactivity for GFAP and a trend towards a decrease in NeuN in the hippocampus. The treatment caused a bioen ergetic impairment in the hippocampus, characterized by a decrease in both O2 consumption related to ATP production and in the maximum respiratory capacity. The thermogenic capacity of brown adipose tissue was impaired by the two-hit protocol, here verified through the absence of a decrease in O2 consumption after uncoupled protein-1 inhibition and an increase in the reserve respiratory capacity. Impaired mitochondrial function was also observed in the liver of HFD+STZ juvenile mice, but not in their heart. These results indicate that exposure to HFD+STZ early in life has a detrimental impact on the bioenergetic and mitochondrial function of tissues with metabolic and thermogenic activities, which is likely related to hippocampal metabolic changes and cognitive impairment.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Ciências Fisiológicas (IB CFS)-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier Inc.-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S0955286323000852?via%3Dihub-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectDieta hiperlipídica-
Palavras-chave: dc.subjectEstreptozotocina-
Palavras-chave: dc.subjectMitocôndria-
Palavras-chave: dc.subjectHipocampo-
Palavras-chave: dc.subjectTecido adiposo marrom-
Palavras-chave: dc.subjectCognição-
Título: dc.titleEarly-life metabolic dysfunction impairs cognition and mitochondrial function in mice-
Aparece nas coleções:Repositório Institucional – UNB

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