PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.creatorMachado, Camila Maria Longo-
Autor(es): dc.creatorSkubal, Magdalena-
Autor(es): dc.creatorHaedicke, Katja-
Autor(es): dc.creatorPittella-Silva, Fabio-
Autor(es): dc.creatorStater, Evan Paul-
Autor(es): dc.creatorSilva, Thais Larissa Araujo de Oliveira-
Autor(es): dc.creatorCosta, Erico Tosoni-
Autor(es): dc.creatorMasotti, Cibele-
Autor(es): dc.creatorOtake, Andreia Hanada-
Autor(es): dc.creatorAndrade, Luciana Nogueira Sousa-
Autor(es): dc.creatorJunqueira, Mara de Souza-
Autor(es): dc.creatorHsiao-Ting Hsu-
Autor(es): dc.creatorDas, Sudeep-
Autor(es): dc.creatorMc Larney, Benedict-
Autor(es): dc.creatorPratt, Edwin Charles-
Autor(es): dc.creatorRomin, Yevgeniy-
Autor(es): dc.creatorNing Fan-
Autor(es): dc.creatorManova-Todorova, Katia-
Autor(es): dc.creatorPomper, Martin-
Autor(es): dc.creatorGrimm, Jan-
Data de aceite: dc.date.accessioned2024-07-22T11:54:53Z-
Data de disponibilização: dc.date.available2024-07-22T11:54:53Z-
Data de envio: dc.date.issued2022-10-06-
Data de envio: dc.date.issued2022-10-06-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/45008-
Fonte completa do material: dc.identifierhttps://doi.org/10.1101/2022.02.25.482024-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-6122-1147-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3446-5415-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-8825-5686-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9644-7098-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-2679-1763-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-7413-4675-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4462-0941-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1303-1220-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-2735-1217-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2404-6543-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-9393-204X-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6165-7431-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6054-6983-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3649-6813-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-0915-6696-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-6753-3010-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-5282-9385-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/791832-
Descrição: dc.descriptionExtracellular vesicles (EV) are comprised of vesicles budding from cell membranes and smaller intracellular vesicles shed by cells. EV play a role in remodeling the tumor microenvironment (TME) and support tumor progression. Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with a carboxypeptidase function, frequently associated with poor clinical prognosis in prostate cancer (PCa). We previously identified an oncogenic PSMA signaling function in prostate cancer. Others demonstrated that EV isolated from the plasma of patients with high-grade PCa carry PSMA, but so far no pathophysiological effect has been associated with PSMA-bearing EV. Here we demonstrate that EV from PCa cells are able to transfer PSMA and its functionality to cells in the TME. The consequence of that EV-mediated PSMA transfer is an acute to long-term increased secretion of vascular endothelial growth factor-A (VEGF-A), angiogenin, pro-angiogenic and pro-lymphangiogenic mediators and increased 4E binding protein 1 (4EBP-1) phosphorylation in tumors. We compare EV from PCa cells with or without PSMA expression to address the role of PSMA-bearing EV in promoting pro-tumoral changes in the TME using classical molecular biology and novel molecular imaging approaches.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Publicador: dc.publisherbioRxiv preprint-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectPróstata - câncer-
Título: dc.titlePSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state-
Aparece nas coleções:Repositório Institucional – UNB

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