BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil

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Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.contributorCentro Universitário do Distrito Federal-
Autor(es): dc.contributorHospital Sírio-Libanês, Brasília-
Autor(es): dc.contributorImagens Médicas de Brasília (IMEB)-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.contributorUniversidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde-
Autor(es): dc.creatorDuarte, Ligia C. A. Cardoso-
Autor(es): dc.creatorFratelli, Caroline Ferreira-
Autor(es): dc.creatorPereira, Alexandre Sampaio Rodrigues-
Autor(es): dc.creatorSouza, Jéssica Nayane Gomes de-
Autor(es): dc.creatorFreitas, Renata de Souza-
Autor(es): dc.creatorMorais, Rafael Martins de-
Autor(es): dc.creatorBarra Sobrinho, Alaor-
Autor(es): dc.creatorSilva, Calliandra Maria de Souza-
Autor(es): dc.creatorOliveira, Jamila Reis de-
Autor(es): dc.creatorOliveira, Diêgo Madureira de-
Autor(es): dc.creatorSilva, Izabel Cristina Rodrigues da-
Data de aceite: dc.date.accessioned2024-07-22T11:48:23Z-
Data de disponibilização: dc.date.available2024-07-22T11:48:23Z-
Data de envio: dc.date.issued2023-10-11-
Data de envio: dc.date.issued2023-10-11-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46665-
Fonte completa do material: dc.identifierhttps://doi.org/10.1177/17246008211057576-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9335-999X-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0511-9452-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9064-0735-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9577-0344-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6836-3583-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/789202-
Descrição: dc.descriptionIntroduction: Papillary thyroid cancer corresponds to approximately 1% of all carcinomas; nevertheless, it is the most prevalent endocrine neoplasm in the world. Studies reveal that the BAX (−248 G > A) polymorphism may be associated with negative regulation of BAX gene transcription activity, causing a decrease in its protein expression. Objective: The present study aimed to describe the genotype and allele frequencies of BAX single nucleotide polymorphisms (−248 G > A) (rs4645878) in the research patients, and to associate its presence with susceptibility to papillary thyroid cancer. Methods: This case-control study was conducted with 30 patients with papillary thyroid cancer. For the evaluation of genetic polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism technique was employed. Allele and genotype frequencies were estimated using the SPSS program, and significant associations were considered when p < 0.05. Results: There was a significant genotypic difference between papillary thyroid cancer and the control group (p = 0.042). The GG genotype provided a protective factor for papillary thyroid cancer (p = 0.012, odds ratio (OR) = 0.313; confidence inter- val (CI) = 0.123–0.794). Likewise the G allele was a protective factor for papillary thyroid cancer (p = 0.009; OR = 0.360; CI = 0.163–0.793). The BAX gene polymorphism (−248 G > A) was associated with papillary thyroid cancer. Conclusion: BAX (−248 G > A) GG genotype carriers, or at least one mutated allele, was associated with papillary thyroid cancer in the Brazilian population studied, and the G allele presence is considered a protective factor against papillary thyroid cancer occurrence.-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências e Tecnologias em Saúde-
Formato: dc.formatapplication/pdf-
Idioma: dc.languagept_BR-
Publicador: dc.publisherSage-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).-
Palavras-chave: dc.subjectPolimorfismo (Genética)-
Palavras-chave: dc.subjectTireóide - câncer-
Título: dc.titleBAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil-
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