Downregulation of histone methyltransferase EHMT2 in CD4+ T-cells may protect HTLV-1-infected individuals against HAM/TSP development

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Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo, Centro de Hemoterapia de Ribeirão Preto-
Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.contributorUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer-
Autor(es): dc.creatorColaço, Camila Schoueri-
Autor(es): dc.creatorMatos, Adriano Reis de-
Autor(es): dc.creatorEstrêla, Martha Silva-
Autor(es): dc.creatorRocha Júnior, Maurício Cristiano-
Autor(es): dc.creatorOtaguiri, Kátia Kaori-
Autor(es): dc.creatorRodrigues, Evandra Strazza-
Autor(es): dc.creatorTakayanagui, Osvaldo Massaiti-
Autor(es): dc.creatorCovas, Dimas Tadeu-
Autor(es): dc.creatorKashima, Simone-
Autor(es): dc.creatorPittella-Silva, Fabio-
Autor(es): dc.creatorHaddad, Rodrigo-
Data de aceite: dc.date.accessioned2024-07-22T11:45:56Z-
Data de disponibilização: dc.date.available2024-07-22T11:45:56Z-
Data de envio: dc.date.issued2022-10-03-
Data de envio: dc.date.issued2022-10-03-
Data de envio: dc.date.issued2017-06-12-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/44950-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s00705-017-3428-8-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/788182-
Descrição: dc.descriptionApproximately 5% of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals will develop one of the HTLV-1-related diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia. However, the mechanisms responsible for the appearance of symptoms have not been fully clarified. It is believed that viral factors, host genetic and epigenetic mechanisms are implicated in this process. Studies have shown the involvement of histone methyltransferases in retrovirus infection, but no study observed their expression in HTLV-1-infected patients. Among them, euchromatic histone-lysine N-methyltransferase (EHMT)-1 and EHMT-2 were related to retroviral latency in HIV-1 infection. We investigated whether histone methyltransferases EHMT1 and EHMT2 exert any influence on HAM/TSP development by assessing their expression levels in CD4+ T-cells from HTLV–1–infected patients. CD4+ T-cells were immunomagnetically isolated from peripheral blood mononuclear cells of HTLV-1-infected or non–infected individuals and the expression levels of EHMT1 and EHMT2 were determined by RT-qPCR. We observed that EHMT2 was negatively regulated in HTLV-1 asymptomatic carriers compared to non-infected individuals. No difference was observed for EHMT1. These results suggest that EHMT2 downregulation in CD4+ T-cells may be linked to a protection mechanism against the development of HAM/TSP.-
Publicador: dc.publisherSpringer-
Relação: dc.relationhttps://link.springer.com/article/10.1007/s00705-017-3428-8-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectVírus da leucemia-
Palavras-chave: dc.subjectMielopatia-
Palavras-chave: dc.subjectHistonas-
Palavras-chave: dc.subjectMetiltransferases-
Título: dc.titleDownregulation of histone methyltransferase EHMT2 in CD4+ T-cells may protect HTLV-1-infected individuals against HAM/TSP development-
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