Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides

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Autor(es): dc.creatorBrango Vanegas, José-
Autor(es): dc.creatorMartinho, Luan Alves-
Autor(es): dc.creatorBessa, Lucinda J.-
Autor(es): dc.creatorVasconcelos, Andreanne Gomes-
Autor(es): dc.creatorPlácido, Alexandra-
Autor(es): dc.creatorPereira, Alex Leite-
Autor(es): dc.creatorLeite, José Roberto de Souza de Almeida-
Autor(es): dc.creatorMachado, Angelo Henrique de Lira-
Data de aceite: dc.date.accessioned2024-07-22T11:43:13Z-
Data de disponibilização: dc.date.available2024-07-22T11:43:13Z-
Data de envio: dc.date.issued2020-01-29-
Data de envio: dc.date.issued2020-01-29-
Data de envio: dc.date.issued2019-10-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/36752-
Fonte completa do material: dc.identifierhttps://doi.org/10.3762%2Fbjoc.15.247-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4070-9770-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-6658-5847-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8339-1964-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-2706-7777-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0346-7146-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1096-3236-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4284-9929-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/787139-
Descrição: dc.descriptionEight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic feature of the MBH residue and represents a new cyclization strategy occurring. The analogues were prepared in moderate overall yields and did not show toxic effects on Staphylococcus aureus growth and were not toxic to human fibroblasts. Two of them inhibited the hemolytic activity of S. aureus, suggesting an interfering action in the bacterial quorum sensing similar to the one already reported for solonamides.-
Descrição: dc.descriptionInstituto de Química (IQ)-
Formato: dc.formatapplication/pdf-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsThis is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.-
Palavras-chave: dc.subjectAgentes antivirais-
Palavras-chave: dc.subjectBactérias-
Palavras-chave: dc.subjectPeptídeos-
Título: dc.titleSynthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides-
Aparece nas coleções:Repositório Institucional – UNB

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