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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Santos, Andressa Borges | - |
Autor(es): dc.creator | Garcia, Suzane | - |
Autor(es): dc.creator | Eduardo, José C. C. | - |
Autor(es): dc.creator | Mesquita, Claudio Tinoco | - |
Autor(es): dc.creator | Lugon, Jocemir R. | - |
Autor(es): dc.creator | Matos, Jorge P. Strogoff | - |
Data de aceite: dc.date.accessioned | 2024-07-11T18:02:10Z | - |
Data de disponibilização: dc.date.available | 2024-07-11T18:02:10Z | - |
Data de envio: dc.date.issued | 2023-05-16 | - |
Data de envio: dc.date.issued | 2023-05-16 | - |
Data de envio: dc.date.issued | 2019 | - |
Fonte completa do material: dc.identifier | http://app.uff.br/riuff/handle/1/28845 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/762263 | - |
Descrição: dc.description | Background. Glomerular filtration rate (GFR) is usually estimated from equations using serum creatinine (sCr), with adjustment for gender, age, and race (black or nonblack). -e Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is the preferred equation for adults, but it was validated for the United States population. We intended to evaluate if the race-ethnicity adjustment proposed for the sCr-based CKD-EPI equations is appropriate for the Brazilian population. Methods. CKD outpatients had blood samples collected for determination of sCr and serum cystatin C (sCys) levels. GFR was measured (mGFR) by plasma clearance of 51Cr-EDTA and used as the reference. We compared values of mGFR and estimated GFR (eGFR) by CKD-EPIequations based on sCr (eGFRCr) and on the combination of sCr and sCys (eGFRCr-Cys). For African Brazilian patients, eGFR was calculated either without or with race adjustment. Accuracy was considered acceptable if the difference between the values of eGFR and mGFR was ≤30% (P30). Results. 100 patients were enrolled (58 ± 14 years, 46% male, 39% white and 61% African Brazilian). Mean mGFR was 46.7 ± 29.2 ml/min/1.73m2. Mean eGFRCr and eGFRCr-Cys without race adjustment were 47.8 ± 30.1 ml/min/1.73m2 and 46.4 ± 30.3 ml/min/1.73m2, respectively. -e corresponding P30 accuracy values were 79.0% and 83.0%. In the African Brazilian subgroup, values for mean mGFR and eGFRCr either without or with race adjustment were 49.8 ± 32.2 ml/min/1.73m2, 50.4 ± 32.7 ml/min/1.73m2, and 58.4 ± 37.9 ml/min/1.73m2 (P < 0.001 vs. mGFR), respectively. P30 accuracy values for eGFRCr either without or with race adjustment were 75.4% and 67.2%, respectively. Conclusions. -e use of CKD-EPI equations without race-ethnicity adjustment seems more appropriate for the Brazilian population. | - |
Descrição: dc.description | Sim | - |
Formato: dc.format | application/pdf | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Hindawi Limited | - |
Publicador: dc.publisher | Niterói, RJ | - |
Relação: dc.relation | INTERNATIONAL JOURNAL OF NEPHROLOGY, United Kingdon: Hindawi. 2010-2023. Anual. ISSN: 2090-2158 | - |
Direitos: dc.rights | Open Access | - |
Direitos: dc.rights | CC-BY-SA | - |
Palavras-chave: dc.subject | Taxa de filtração glomerular | - |
Palavras-chave: dc.subject | Raça | - |
Palavras-chave: dc.subject | Etnia | - |
Palavras-chave: dc.subject | Doença renal crônica | - |
Palavras-chave: dc.subject | Brasileiro | - |
Título: dc.title | No race-ethnicity adjustment in CKD-EPI equations Is required for estimating glomerular filtration rate in the brazilian population | - |
Título: dc.title | No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population | - |
Tipo de arquivo: dc.type | Artigo de periódicos | - |
Aparece nas coleções: | Repositório Institucional da Universidade Federal Fluminense - RiUFF |
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