No race-ethnicity adjustment in CKD-EPI equations Is required for estimating glomerular filtration rate in the brazilian population

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSantos, Andressa Borges-
Autor(es): dc.creatorGarcia, Suzane-
Autor(es): dc.creatorEduardo, José C. C.-
Autor(es): dc.creatorMesquita, Claudio Tinoco-
Autor(es): dc.creatorLugon, Jocemir R.-
Autor(es): dc.creatorMatos, Jorge P. Strogoff-
Data de aceite: dc.date.accessioned2024-07-11T18:02:10Z-
Data de disponibilização: dc.date.available2024-07-11T18:02:10Z-
Data de envio: dc.date.issued2023-05-16-
Data de envio: dc.date.issued2023-05-16-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://app.uff.br/riuff/handle/1/28845-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/762263-
Descrição: dc.descriptionBackground. Glomerular filtration rate (GFR) is usually estimated from equations using serum creatinine (sCr), with adjustment for gender, age, and race (black or nonblack). -e Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is the preferred equation for adults, but it was validated for the United States population. We intended to evaluate if the race-ethnicity adjustment proposed for the sCr-based CKD-EPI equations is appropriate for the Brazilian population. Methods. CKD outpatients had blood samples collected for determination of sCr and serum cystatin C (sCys) levels. GFR was measured (mGFR) by plasma clearance of 51Cr-EDTA and used as the reference. We compared values of mGFR and estimated GFR (eGFR) by CKD-EPIequations based on sCr (eGFRCr) and on the combination of sCr and sCys (eGFRCr-Cys). For African Brazilian patients, eGFR was calculated either without or with race adjustment. Accuracy was considered acceptable if the difference between the values of eGFR and mGFR was ≤30% (P30). Results. 100 patients were enrolled (58 ± 14 years, 46% male, 39% white and 61% African Brazilian). Mean mGFR was 46.7 ± 29.2 ml/min/1.73m2. Mean eGFRCr and eGFRCr-Cys without race adjustment were 47.8 ± 30.1 ml/min/1.73m2 and 46.4 ± 30.3 ml/min/1.73m2, respectively. -e corresponding P30 accuracy values were 79.0% and 83.0%. In the African Brazilian subgroup, values for mean mGFR and eGFRCr either without or with race adjustment were 49.8 ± 32.2 ml/min/1.73m2, 50.4 ± 32.7 ml/min/1.73m2, and 58.4 ± 37.9 ml/min/1.73m2 (P < 0.001 vs. mGFR), respectively. P30 accuracy values for eGFRCr either without or with race adjustment were 75.4% and 67.2%, respectively. Conclusions. -e use of CKD-EPI equations without race-ethnicity adjustment seems more appropriate for the Brazilian population.-
Descrição: dc.descriptionSim-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherHindawi Limited-
Publicador: dc.publisherNiterói, RJ-
Relação: dc.relationINTERNATIONAL JOURNAL OF NEPHROLOGY, United Kingdon: Hindawi. 2010-2023. Anual. ISSN: 2090-2158-
Direitos: dc.rightsOpen Access-
Direitos: dc.rightsCC-BY-SA-
Palavras-chave: dc.subjectTaxa de filtração glomerular-
Palavras-chave: dc.subjectRaça-
Palavras-chave: dc.subjectEtnia-
Palavras-chave: dc.subjectDoença renal crônica-
Palavras-chave: dc.subjectBrasileiro-
Título: dc.titleNo race-ethnicity adjustment in CKD-EPI equations Is required for estimating glomerular filtration rate in the brazilian population-
Título: dc.titleNo Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population-
Tipo de arquivo: dc.typeArtigo de periódicos-
Aparece nas coleções:Repositório Institucional da Universidade Federal Fluminense - RiUFF

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