Skin regenerative potential of Cupuaçu seed extract (Theobroma grandiflorum), a native fruit from the Amazon : development of a topical formulation based on chitosan-coated nanocapsules

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Autor(es): dc.creatorBarbalho, Geisa Nascimento-
Autor(es): dc.creatorMatos, Breno Noronha-
Autor(es): dc.creatorBrito, Gabriel Ferreira da Silva-
Autor(es): dc.creatorMiranda, Thamires da Cunha-
Autor(es): dc.creatorAlencar-Silva, Thuany-
Autor(es): dc.creatorFabriz Sodré, Fernando-
Autor(es): dc.creatorGelfuso, Guilherme Martins-
Autor(es): dc.creatorCunha Filho, Marcílio Sérgio Soares da-
Autor(es): dc.creatorCarvalho, Juliana Lott-
Autor(es): dc.creatorSilva, Joyce Kelly do Rosário da-
Autor(es): dc.creatorGratieri, Taís-
Data de aceite: dc.date.accessioned2022-08-15T13:37:39Z-
Data de disponibilização: dc.date.available2022-08-15T13:37:39Z-
Data de envio: dc.date.issued2022-04-26-
Data de envio: dc.date.issued2022-04-26-
Data de envio: dc.date.issued2022-01-15-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/43541-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/pharmaceutics14010207-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0002-9605-4171-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0002-1924-7885-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0002-9167-6852-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0001-6481-2364-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/713320-
Descrição: dc.descriptionScarless skin regeneration is a challenge in regenerative medicine. Herein, we explore the regenerative potential of a Cupuaçu seed extract (Theobroma grandiflorum) to develop an innovative skin regeneration formulation based on chitosan-coated nanocapsules. Cupuaçu seed extract significantly stimulated cell proliferation and migration. A reparative gene expression profile could be verified following extract treatment, which included high levels of MKI67, a cellular proliferation marker, and extracellular matrix genes, such as ELN and HAS2, which code for elastin and hyaluronic acid synthase 2. Formulations with Cupuaçu seed extract successfully entrapped into nanocapsules (EE% > 94%) were developed. Uncoated or coated nanocapsules with low-molecular-weight chitosan presented unimodal size distribution with hydrodynamic diameters of 278.3 ± 5.0 nm (PDI = 0.18 ± 0.02) and 337.2 ± 2.1 nm (PDI = 0.27 ± 0.01), respectively. Both nanosystems were physically stable for at least 120 days and showed to be non-irritating to reconstructed human epidermis. Chitosan coating promoted active penetration into undamaged skin areas, which were still covered by the stratum corneum. In conclusion, the present study demonstrated for the first time the biotechnological potential of the frequently discarded Cupuaçu seed as a valuable pharmaceutical ingredient to be used in regenerative skin products.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectNanocápsulas-
Palavras-chave: dc.subjectExtrato de semente de cupuaçu-
Palavras-chave: dc.subjectPele - queimaduras-
Palavras-chave: dc.subjectPele - regeneração-
Palavras-chave: dc.subjectÁcido oleico-
Título: dc.titleSkin regenerative potential of Cupuaçu seed extract (Theobroma grandiflorum), a native fruit from the Amazon : development of a topical formulation based on chitosan-coated nanocapsules-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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