Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCampos, Natália Aboudib-
Autor(es): dc.creatorCunha, Marcela de Sá Barreto da-
Autor(es): dc.creatorArruda, Sandra Fernandes-
Data de aceite: dc.date.accessioned2022-02-10T21:13:40Z-
Data de disponibilização: dc.date.available2022-02-10T21:13:40Z-
Data de envio: dc.date.issued2021-11-23-
Data de envio: dc.date.issued2021-11-23-
Data de envio: dc.date.issued2018-11-14-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/42426-
Fonte completa do material: dc.identifierhttps://doi.org/10.1371/journal.pone.0206670-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0003-1518-2217-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0002-1388-033X-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/647690-
Descrição: dc.descriptionOxidative and inflammatory responses play an important role in the development and prevention of cancer, with both responses being modulated by phytochemical compounds. This study investigated the chemopreventive effect of tucum-do-cerrado fruit in rats treated with azoxymethane. Wistar rats were treated for 12 weeks with: a control diet (CT); a control diet + AOM (CT/DR); a control diet + 15% tucum-do-cerrado (TU); or a control diet + 15% tucum-do-cerrado + AOM (TU/DR). The association of tucum-do-cerrado and AOM (TU/ DR) increased glutathione-S-transferase activity, decreased MDA levels, increased levels of COX2, TNFα and BAX, and decreased Bcl2/Bax ratio, compared to the CT/DR group. Carbonyl levels, IL-1β and IL-6 mRNA levels, and aberrant crypt foci showed no difference between the treatments. In conclusion, tucum-do-cerrado reduced lipid oxidative damage, induced a pro-inflammatory effect, and promoted a pro-apoptotic “environment” in rats treated with AOM; however no changes in aberrant crypts were observed.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherPLoS ONE-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2018 Campos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
Palavras-chave: dc.subjectTucum-
Palavras-chave: dc.subjectStress oxidativo-
Palavras-chave: dc.subjectInflamação-
Palavras-chave: dc.subjectProteínas-
Título: dc.titleTucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.