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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Arruda, Sandra Fernandes | - |
Autor(es): dc.creator | Ramos, Larissa Valadares | - |
Autor(es): dc.creator | Barbosa, Júlia Lima de Alencar | - |
Autor(es): dc.creator | Hankins, Natália Aboudib Campos | - |
Autor(es): dc.creator | Rodrigues, Pedro Augusto Matos | - |
Autor(es): dc.creator | Cunha, Marcela de Sá Barreto da | - |
Data de aceite: dc.date.accessioned | 2022-02-10T21:12:44Z | - |
Data de disponibilização: dc.date.available | 2022-02-10T21:12:44Z | - |
Data de envio: dc.date.issued | 2021-11-23 | - |
Data de envio: dc.date.issued | 2021-11-23 | - |
Data de envio: dc.date.issued | 2020-05-22 | - |
Fonte completa do material: dc.identifier | https://repositorio.unb.br/handle/10482/42425 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.3390/nu12051515 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/647537 | - |
Descrição: dc.description | The Brazilian savanna fruit, tucum-do-cerrado (Bactris setosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tucum-do-cerrado (Tuc); iron-enriched diet (+Fe); or iron-enriched diet +15% tucum-do-cerrado (Tuc+Fe). Tucum-do-cerrado (Tuc) decreased hepatic Hamp and Hjv mRNA levels but did not alter Bmp6, Smad7, Tfr1, and Hfe mRNA levels; pSMAD1/5/8 and pSTAT3 protein levels; labile iron pool (LIP); and inflammatory biomarkers, compared to the CT group. The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group. The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group. Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content. However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | MDPI | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | (CC BY) © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
Palavras-chave: dc.subject | Tucum | - |
Palavras-chave: dc.subject | Hepcidina | - |
Palavras-chave: dc.subject | Proteínas | - |
Palavras-chave: dc.subject | Ferro | - |
Título: dc.title | The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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