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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Nunes, Ricardo Ferreira | - |
Autor(es): dc.creator | Cunha Filho, Marcílio Sérgio Soares da | - |
Autor(es): dc.creator | Gratieri, Taís | - |
Autor(es): dc.creator | Gelfuso, Guilherme Martins | - |
Data de aceite: dc.date.accessioned | 2022-02-10T21:11:53Z | - |
Data de disponibilização: dc.date.available | 2022-02-10T21:11:53Z | - |
Data de envio: dc.date.issued | 2021-11-09 | - |
Data de envio: dc.date.issued | 2021-11-09 | - |
Data de envio: dc.date.issued | 2020 | - |
Fonte completa do material: dc.identifier | https://repositorio.unb.br/handle/10482/42350 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.1016/j.colsurfb.2021.112101 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/647392 | - |
Descrição: dc.description | This study proposes developing a topical formulation based on poly-ε-caprolactone (PCL) or methacrylic acid/methyl methacrylate copolymer (EL100) nanoparticles to enable a safer and more effective therapy of alopecia and acne with spironolactone. The effect of the size of the nanoparticle on follicular-targeted drug delivery is also verified. Compatibility studies based on thermal analyses and complementary techniques showed a small interaction of the drug with excipients, which may not compromise the drug stability. PCL nanoparticles of 180.0 ± 1.6 and 126.8 ± 1.0 nm, and EL100 nanoparticles of 102.7 ± 7.1 nm were then prepared. All nanoparticles entrapped more than 75 % of spironolactone, were physically stable, and stabilized the drug for at least 90 days. They were also non-irritant according to HET-CAM tests. Drug release from the nanoparticles was reduced in aqueous buffer media but fast when in contact with oil. Finally, in vitro skin penetration experiments revealed the largest nanoparticles (of 180 nm) targeted drug delivery to the hair follicles 5-fold (p < 0.05) more than the control solution, 2.1-fold (p < 0.05) more than nanoparticles produced with the same polymer (PCL) but with smaller size (123 nm), and 4.9-fold (p < 0.05) more than the 102-nm E100 nanoparticles. In conclusion, follicular targeting can be adjusted according to nanoparticle size, and this work succeeded in obtaining polymeric nanoparticles adequate to enable topical treatment of acne and alopecia with spironolactone. | - |
Publicador: dc.publisher | Elsevier B.V. | - |
Relação: dc.relation | https://www.sciencedirect.com/science/article/abs/pii/S0927776521005452?via%3Dihub | - |
Direitos: dc.rights | Acesso Restrito | - |
Palavras-chave: dc.subject | Acne | - |
Palavras-chave: dc.subject | Alopecia | - |
Palavras-chave: dc.subject | Folículo capilar | - |
Palavras-chave: dc.subject | Copolímero de ácido metacrílico / metacrilato de metila | - |
Palavras-chave: dc.subject | Poli-ε-caprolactona | - |
Título: dc.title | Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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