Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults

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Autor(es): dc.creatorPaula, Roberta S.-
Autor(es): dc.creatorSouza, Vinícius C.-
Autor(es): dc.creatorMachado-Silva, Wilcelly-
Autor(es): dc.creatorAlmeida, Bruno Ratier S.-
Autor(es): dc.creatorDaros, Andersen C.-
Autor(es): dc.creatorGomes, Lucy-
Autor(es): dc.creatorFerreira, Aparecido P.-
Autor(es): dc.creatorBrito, Ciro J.-
Autor(es): dc.creatorCórdova, Cláudio-
Autor(es): dc.creatorMoraes, Clayton F.-
Autor(es): dc.creatorNóbrega, Otávio T.-
Data de aceite: dc.date.accessioned2021-10-14T18:48:22Z-
Data de disponibilização: dc.date.available2021-10-14T18:48:22Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2016-12-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/30394-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.6061/clinics/2016(12)09-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/640363-
Descrição: dc.descriptionThe number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherFaculdade de Medicina / USP-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsClinics - This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200725&lng=en&nrm=iso. Acesso em: 18 dez. 2017.-
Palavras-chave: dc.subjectBiomarcadores-
Palavras-chave: dc.subjectIdosos-
Palavras-chave: dc.subjectInfarto-
Título: dc.titleSerum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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