Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLins, Tulio Cesar de Lima-
Autor(es): dc.creatorPires, Alause da Silva-
Autor(es): dc.creatorPaula, Roberta da Silva-
Autor(es): dc.creatorMoraes, Clayton Franco-
Autor(es): dc.creatorVieira, Rodrigo G.-
Autor(es): dc.creatorVianna, Lucy Gomes-
Autor(es): dc.creatorNóbrega, Otávio de Tolêdo-
Autor(es): dc.creatorPereira, Rinaldo Wellerson-
Data de aceite: dc.date.accessioned2021-10-14T18:48:14Z-
Data de disponibilização: dc.date.available2021-10-14T18:48:14Z-
Data de envio: dc.date.issued2012-11-28-
Data de envio: dc.date.issued2012-11-28-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/11704-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1415-47572012005000047-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/640314-
Descrição: dc.descriptionThe prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherSociedade Brasileira de Genética-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsGenetics and Molecular Biology - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0 ). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=1415-4757&lng=pt&nrm=iso. Acesso em: 27 nov. 2012.-
Palavras-chave: dc.subjectMulheres - nutrição-
Palavras-chave: dc.subjectMulheres idosas-
Palavras-chave: dc.subjectObesidade em mulheres-
Palavras-chave: dc.subjectGenética de populações-
Palavras-chave: dc.subjectMulheres - saúde e higiene-
Título: dc.titleAssociation of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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