Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage

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Autor(es): dc.creatorMorais Júnior, Gilberto Santos-
Autor(es): dc.creatorKurizky, Patricia Shu-
Autor(es): dc.creatorCerqueira, Selma Regina Penha Silva-
Autor(es): dc.creatorBarroso, Daniel Holanda-
Autor(es): dc.creatorSchulte, Heidi Luise-
Autor(es): dc.creatorAlbuquerque, Cleandro Pires de-
Autor(es): dc.creatorGois, Eliana Teles de-
Autor(es): dc.creatorEspindola, Laila Salmen-
Autor(es): dc.creatorSantana, Jaime Martins de-
Autor(es): dc.creatorBastos, Izabela Marques Dourado-
Autor(es): dc.creatorAraújo, Carla Nunes de-
Autor(es): dc.creatorMota, Licia Maria Henrique da-
Autor(es): dc.creatorNóbrega, Otávio de Tolêdo-
Autor(es): dc.creatorGomes, Ciro Martins-
Data de aceite: dc.date.accessioned2021-10-14T18:35:40Z-
Data de disponibilização: dc.date.available2021-10-14T18:35:40Z-
Data de envio: dc.date.issued2021-07-30-
Data de envio: dc.date.issued2021-07-30-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/41534-
Fonte completa do material: dc.identifierhttps://doi.org/10.4269/ajtmh.21-0034-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/635354-
Descrição: dc.descriptionExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherAmerican Society of Tropical Medicine and Hygiene-
Relação: dc.relationhttps://repositorio.unb.br/handle/10482/40909-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
Palavras-chave: dc.subjectHanseníase-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectCovid-19-
Título: dc.titleEnhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage-
Tipo de arquivo: dc.typelivro digital-
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