Dietary iron concentration may influence aging process by altering oxidative stress in tissues of adult rats

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorArruda, Lorena Fernandes-
Autor(es): dc.creatorArruda, Sandra Fernandes-
Autor(es): dc.creatorCampos, Natália Aboudib-
Autor(es): dc.creatorValencia, Fernando Fortes de-
Autor(es): dc.creatorSiqueira, Egle Machado de Almeida-
Data de aceite: dc.date.accessioned2021-10-14T18:34:27Z-
Data de disponibilização: dc.date.available2021-10-14T18:34:27Z-
Data de envio: dc.date.issued2013-08-19-
Data de envio: dc.date.issued2013-08-19-
Data de envio: dc.date.issued2013-04-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/13983-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1371/journal.pone.0061058-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/634873-
Descrição: dc.descriptionIron is an essential element. However, in its free form, iron participates in redox-reactions, leading to the production of free radicals that increase oxidative stress and the risk of damaging processes. Living organisms have an efficient mechanism that regulates iron absorption according to their iron content to protect against oxidative damage. The effects of restricted and enriched-iron diets on oxidative stress and aging biomarkers were investigated. Adult Wistar rats were fed diets containing 10, 35 or 350 mg/kg iron (adult restricted-iron, adult control-iron and adult enriched-iron groups, respectively) for 78 days. Rats aged two months were included as a young control group. Young control group showed higher hemoglobin and hematocrit values, lower levels of iron and lower levels of MDA or carbonyl in the major studied tissues than the adult control group. Restricted-iron diet reduced iron concentrations in skeletal muscle and oxidative damage in the majority of tissues and also increased weight loss. Enriched-iron diet increased hematocrit values, serum iron, gammaglutamyl transferase, iron concentrations and oxidative stress in the majority of tissues. As expected, young rats showed higher mRNA levels of heart and hepatic L-Ferritin (Ftl) and kidneys SMP30 as well as lower mRNA levels of hepatic Hamp and interleukin-1 beta (Il1b) and also lower levels of liver protein ferritin. Restricted-iron adult rats showed an increase in heart Ftl mRNA and the enriched-iron adult rats showed an increase in liver nuclear factor erythroid derived 2 like 2 (Nfe2l2) and Il1b mRNAs and in gut divalent metal transporter-1 mRNA (Slc11a2) relative to the control adult group. These results suggest that iron supplementation in adult rats may accelerate aging process by increasing oxidative stress while iron restriction may retards it. However, iron restriction may also impair other physiological processes that are not associated with aging.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherPLOS-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2013 Arruda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061058.-
Palavras-chave: dc.subjectFerro no organismo-
Palavras-chave: dc.subjectStress oxidativo-
Palavras-chave: dc.subjectDeficiência de ferro-
Título: dc.titleDietary iron concentration may influence aging process by altering oxidative stress in tissues of adult rats-
Tipo de arquivo: dc.typelivro digital-
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