Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice

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Autor(es): dc.creatorSantarem, Ana Angélica Amorim-
Autor(es): dc.creatorGreggianin, Gabriel Frizon-
Autor(es): dc.creatorDebastiani, Rafaela Garcia-
Autor(es): dc.creatorRibeiro, Jefferson Bruno Pereira-
Autor(es): dc.creatorPolli, Demerson Andre-
Autor(es): dc.creatorSampaio, Raimunda Nonata Ribeiro-
Data de aceite: dc.date.accessioned2021-10-14T18:30:11Z-
Data de disponibilização: dc.date.available2021-10-14T18:30:11Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2014-08-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/29126-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/0037-8682-0202-2013-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/633229-
Descrição: dc.descriptionIntroduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira de Medicina Tropical - SBMT-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsRevista da Sociedade Brasileira de Medicina Tropical - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tln g=en. Acesso em: 27 jul. 2020.-
Palavras-chave: dc.subjectLeishmaniose cutânea-
Palavras-chave: dc.subjectPentoxifilina-
Palavras-chave: dc.subjectMiltefosina-
Título: dc.titleEffectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice-
Tipo de arquivo: dc.typelivro digital-
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