Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMatos, Breno N.-
Autor(es): dc.creatorMelo, Larissa M. A.-
Autor(es): dc.creatorPereira, Maíra N.-
Autor(es): dc.creatorReis, Thaiene A.-
Autor(es): dc.creatorCunha-Filho, Marcílio-
Autor(es): dc.creatorGratieri, Taís-
Autor(es): dc.creatorGelfuso, Guilherme Martins-
Data de aceite: dc.date.accessioned2021-10-14T18:26:22Z-
Data de disponibilização: dc.date.available2021-10-14T18:26:22Z-
Data de envio: dc.date.issued2018-01-04-
Data de envio: dc.date.issued2018-01-04-
Data de envio: dc.date.issued2017-02-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/30601-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20160159-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/631675-
Descrição: dc.descriptionThe experiments described in this paper tested the hypothesis whether iontophoresis applied on a chitosan nanoparticle formulation could combine the enhanced drug accumulation into the follicular casts obtained using iontophoresis and the sustained drug release, reducing dermal exposure, provided by nanoparticles. Results showed that even though iontophoresis presented comparable minoxidil targeting potential to hair follicles than passive delivery of chitosan-nanoparticles (4.1 ± 0.9 and 5.3 ± 1.0 µg cm-2, respectively), it was less effective on preventing dermal exposure, since chitosan-nanoparticles presented a drug permeation in the receptor solution of 15.3 ± 4.3 µg cm-2 after 6 h of iontophoresis, while drug amounts from passive nanoparticle delivery were not detected. Drug release experiments showed particles were not able to sustain the drug release under the influence of a potential gradient. In conclusion, the application of MXS-loaded chitosan nanoparticles remains the best way to target MXS to the hair follicles while preventing dermal exposure.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira de Química-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsQuímica Nova - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000200154&lng=en&nrm=iso. Acesso em: 21 fev. 2018.-
Palavras-chave: dc.subjectQuitosana-
Palavras-chave: dc.subjectNanopartículas-
Palavras-chave: dc.subjectPele-
Título: dc.titleIontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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