Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorVieira, Michele Juliane-
Autor(es): dc.creatorPerosa, Sandra Regina-
Autor(es): dc.creatorArgañaraz, Gustavo Adolfo-
Autor(es): dc.creatorSilva Junior, José Antônio-
Autor(es): dc.creatorCavalheiro, Esper Abrão-
Autor(es): dc.creatorNaffah-Mazzacoratti, Maria da Graça-
Data de aceite: dc.date.accessioned2021-10-14T18:16:18Z-
Data de disponibilização: dc.date.available2021-10-14T18:16:18Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2014-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/29416-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.6061/clinics/2014(09)08-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/627586-
Descrição: dc.descriptionOBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherFaculdade de Medicina / USP-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsClinics - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso&tlng=en. Acesso em: 30 out. 2019.-
Palavras-chave: dc.subjectAnti-inflamatórios-
Palavras-chave: dc.subjectInflamação-
Palavras-chave: dc.subjectEpilepsia-
Título: dc.titleIndomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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