High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRomero, Gustavo Adolfo Sierra-
Autor(es): dc.creatorFlores, Érico Marlon de Moraes-
Autor(es): dc.creatorNoronha, Elza Ferreira-
Autor(es): dc.creatorMacêdo, Vanize de Oliveira-
Data de aceite: dc.date.accessioned2021-10-14T18:14:06Z-
Data de disponibilização: dc.date.available2021-10-14T18:14:06Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2003-01-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/25981-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0074-02762003000100019-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/626691-
Descrição: dc.descriptionWe analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&tlng=en. Acesso em: 04 dez. 2020.-
Palavras-chave: dc.subjectMedicamentos - análise-
Palavras-chave: dc.subjectMetais pesados-
Palavras-chave: dc.subjectLeishmaniose cutânea-
Palavras-chave: dc.subjectChumbo-
Palavras-chave: dc.subjectArsênio-
Palavras-chave: dc.subjectToxidade-
Palavras-chave: dc.subjectEfeitos adversos-
Título: dc.titleHigh frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls-
Tipo de arquivo: dc.typelivro digital-
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