Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAlecrim, Hugo Muscelli-
Autor(es): dc.creatorDuarte, Sérgio Andurte Carvalho-
Autor(es): dc.creatorAmaral, Maria Eduarda Bonavides-
Autor(es): dc.creatorDiógenis, Filipe-
Autor(es): dc.creatorCarneiro, Fabiana Pirani-
Autor(es): dc.creatorSousa, João Batista de-
Data de aceite: dc.date.accessioned2021-10-14T18:14:00Z-
Data de disponibilização: dc.date.available2021-10-14T18:14:00Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2015-01-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/29648-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0102-86502015001000010-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/626652-
Descrição: dc.descriptionPurpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsActa Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso. Acesso em: 17 abr. 2018.-
Palavras-chave: dc.subjectCólon (Anatomia)-
Palavras-chave: dc.subjectCicatrização de feridas-
Palavras-chave: dc.subjectCirurgia-
Palavras-chave: dc.subjectRatos-
Título: dc.titleEffect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction-
Tipo de arquivo: dc.typelivro digital-
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