Catalyzed and non-catalyzed synthesis of bioactive monastrol

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Autor(es): dc.creatorAlvim, Haline Gerica de Oliveira-
Autor(es): dc.creatorCorrêa, José Raimundo-
Autor(es): dc.creatorMachado, Taynara Rezende-
Autor(es): dc.creatorSilva, Wender Alves da-
Autor(es): dc.creatorNeto, Brenno A.-
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Descrição: dc.descriptionThe bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira de Química-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsQuímica Nova - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: m=iso&tlng=en. Acesso em: 20 jul. 2020.-
Palavras-chave: dc.subjectMonastrol-
Palavras-chave: dc.subjectReação de Biginelli-
Palavras-chave: dc.subjectCatálise-
Título: dc.titleCatalyzed and non-catalyzed synthesis of bioactive monastrol-
Tipo de arquivo: dc.typelivro digital-
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