Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCaramelli, Bruno-
Autor(es): dc.creatorBernoche, Claudia Y.S.M. de-
Autor(es): dc.creatorSartori, Ana M.C-
Autor(es): dc.creatorSpósito, Andrei Carvalho-
Autor(es): dc.creatorSantos, Raul D.-
Autor(es): dc.creatorMonachini, Maristela C.-
Autor(es): dc.creatorStrabelli, Tania-
Autor(es): dc.creatorUip, Davi-
Data de aceite: dc.date.accessioned2021-10-14T17:53:31Z-
Data de disponibilização: dc.date.available2021-10-14T17:53:31Z-
Data de envio: dc.date.issued2010-03-26-
Data de envio: dc.date.issued2010-03-26-
Data de envio: dc.date.issued2001-12-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/4026-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/618619-
Descrição: dc.description7 f.-
Descrição: dc.descriptionHyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment.-
Formato: dc.formatapplication/pdf-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectColesterol-
Palavras-chave: dc.subjectLipídios-
Palavras-chave: dc.subjectHIV - infecção-
Palavras-chave: dc.subjectTriglicerídios-
Título: dc.titleHyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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