MicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodies

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSousa, Isabel Garcia-
Autor(es): dc.creatorAlmo, Manuela Maragno do-
Autor(es): dc.creatorSimi, Kelly Cristina Rodrigues-
Autor(es): dc.creatorBezerra, Maryani Andressa Gomes-
Autor(es): dc.creatorAndrade, Rosângela Vieira-
Autor(es): dc.creatorMaranhão, Andréa Queiroz-
Autor(es): dc.creatorBrígido, Marcelo de Macedo-
Data de aceite: dc.date.accessioned2021-10-14T17:39:04Z-
Data de disponibilização: dc.date.available2021-10-14T17:39:04Z-
Data de envio: dc.date.issued2017-07-25-
Data de envio: dc.date.issued2017-07-25-
Data de envio: dc.date.issued2017-03-14-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/23881-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1186/s13104-017-2442-y-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/612993-
Descrição: dc.descriptionBackground: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely clear. In T cells, microRNAs (miRNAs) regulate several pathways, including those associated with immune tolerance. Here, we report changes in miRNA expression in T cells following treatment with anti-human CD3 antibodies. Peripheral blood mononuclear cells were cultured in the presence of the monoclonal antibody OKT3 or a recombinant fragment of humanized anti-CD3. Following these treatments, the expression profiles of 31 miRNA species were assessed in T cells using TaqMan arrays. Results: Eight of the tested miRNAs (miR-155, miR-21, miR-146a, miR-210, miR-17, miR-590-5p, miR-106b and miR- 301a) were statistically significantly up- or down-regulated relative to untreated cells. Conclusions: Stimulation of T cells with anti-human CD3 antibodies alters miRNA expression patterns, including of miRNA species associated with immune regulatory pathways.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherBioMed Central-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.-
Palavras-chave: dc.subjectAnticorpos-
Palavras-chave: dc.subjectImunologia-
Título: dc.titleMicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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