GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promotes insulin sensitization without weight gain

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAmato, Angélica Amorim-
Autor(es): dc.creatorRajagopalan, Senapathy-
Autor(es): dc.creatorLin, Jean Z.-
Autor(es): dc.creatorCarvalho, Bruno de Melo-
Autor(es): dc.creatorFigueira, Ana Carolina Migliorini-
Autor(es): dc.creatorLu, Jenny-
Autor(es): dc.creatorAyers, Stephen D.-
Autor(es): dc.creatorMottin, Melina-
Autor(es): dc.creatorSilveira, Rodrigo Leandro-
Autor(es): dc.creatorSouza, Paulo Cesar Telles de-
Autor(es): dc.creatorMourão, Rosa Helena Veras-
Autor(es): dc.creatorSaad, Mário José Abdalla-
Autor(es): dc.creatorTogashi, Marie-
Autor(es): dc.creatorSimeoni, Luiz Alberto-
Autor(es): dc.creatorAbdalla, Dulcineia Saes Parra-
Autor(es): dc.creatorSkaf, Munir Salomao-
Autor(es): dc.creatorPolikarpov, Igor-
Autor(es): dc.creatorLima, Maria do Carmo Alves de-
Autor(es): dc.creatorGaldino, Suely Lins-
Autor(es): dc.creatorBrennan, Richard G.-
Autor(es): dc.creatorBaxter, John Darling-
Autor(es): dc.creatorPitta, Ivan da Rocha-
Autor(es): dc.creatorWebb, Paul-
Autor(es): dc.creatorPhillips, Kevin J.-
Autor(es): dc.creatorNeves, Francisco de Assis Rocha-
Data de aceite: dc.date.accessioned2021-10-14T17:35:00Z-
Data de disponibilização: dc.date.available2021-10-14T17:35:00Z-
Data de envio: dc.date.issued2013-05-17-
Data de envio: dc.date.issued2013-05-17-
Data de envio: dc.date.issued2012-08-10-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/13144-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/611322-
Descrição: dc.descriptionABSTRACT-
Descrição: dc.descriptionBackground: PPAR agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile. Significance: Similar compounds could have promise as anti-diabetic therapeutics.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherThe American Society for Biochemistry and Molecular Biology, Inc.-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsThe Journal of Biological Chemistry - The final version of the manuscript will be covered under the Creative Commons Attribution license (CC BY), the most accommodating of licenses offered. Click here for details.The final version of the manuscript will be released immediately on the publisher’s website and PubMed Central. Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml-
Palavras-chave: dc.subjectResistência à insulina-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectMedicamentos - uso terapêutico-
Palavras-chave: dc.subjectGanho/Perda de peso-
Título: dc.titleGQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promotes insulin sensitization without weight gain-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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