Synthesis, characterization and in vitro anticancer activity of Novel 8,4’ : oxyneolignan analogues

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza, Gisele C.-
Autor(es): dc.creatorFranchi Jr., Gilberto C.-
Autor(es): dc.creatorNowill, Alexandre E.-
Autor(es): dc.creatorSantos, Lourivaldo S.-
Autor(es): dc.creatorAlves, Cláudio N.-
Autor(es): dc.creatorBarata, Lauro E. S.-
Autor(es): dc.creatorAndrade, Carlos Kleber Zago de-
Data de aceite: dc.date.accessioned2021-10-14T17:29:16Z-
Data de disponibilização: dc.date.available2021-10-14T17:29:16Z-
Data de envio: dc.date.issued2018-01-04-
Data de envio: dc.date.issued2018-01-04-
Data de envio: dc.date.issued2017-11-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/30697-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20170075-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/609078-
Descrição: dc.descriptionNeolignans are a class of natural products with a wide range of biological effects. These substances are of great synthetic and biological interest, especially in searching for novel anticancer agents. In this paper, we report the synthesis of a new subclass of 8,4’-oxyneolignan analogues (β-ketoethers and β-ketoesters) and their cell viability assay on twenty four different cancer cells, among leukemias and carcinomas. Three compounds inhibited the growth of most human cancer cells. 2-Oxo-2-phenylethyl(2E)-3-[4-(2-oxo-2-phenylethoxy) phenyl]prop-2-enoate showed an antiproliferative activity superior to doxorubicin for U-87, U-138 MG and H1299 cell types and (E)-2-oxo-2-phenylethyl 3-(3-methoxy-4-(2-oxo-2-phenylethoxy)phenyl)acrylate was found to be very selective, demonstrating a growth inhibition of 92.0% against KG-1 cells. Furthermore, 1-oxo-1-phenylpropan-2-yl cinnamate exhibited significant inhibition activity in a range of 52.2 to 91.2% against twelve kinds of leukemia cell lines, revealing excellent results and very comparable to the reference drug.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira de Química-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsJournal of the Brazilian Chemical Society - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102229&lng=en&nrm=iso. Acesso em: 1 fev. 2017.-
Palavras-chave: dc.subjectCompostos orgânicos-
Palavras-chave: dc.subjectCâncer - tratamento-
Palavras-chave: dc.subjectSíntese-
Título: dc.titleSynthesis, characterization and in vitro anticancer activity of Novel 8,4’ : oxyneolignan analogues-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.