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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Pereira, D.S. | - |
Autor(es): dc.creator | Garcia, D.M. | - |
Autor(es): dc.creator | Narciso, F.M.S. | - |
Autor(es): dc.creator | Santos, M.L.A.S. | - |
Autor(es): dc.creator | Dias, J.M.D. | - |
Autor(es): dc.creator | Queiroz, B.Z. | - |
Autor(es): dc.creator | Souza, E.R. | - |
Autor(es): dc.creator | Nóbrega, O.T. | - |
Autor(es): dc.creator | Pereira, L.S.M. | - |
Data de aceite: dc.date.accessioned | 2021-10-14T17:22:54Z | - |
Data de disponibilização: dc.date.available | 2021-10-14T17:22:54Z | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2011 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/28012 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1590/S0100-879X2010007500152 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/606556 | - |
Descrição: dc.description | We investigated the effect of -174 G/C single-nucleotide polymorphism in the promoter region of the IL6 gene on plasma IL-6 levels and muscle strength, and the relationship between IL-6 levels and muscle strength in elderly women. The sample consisted of 199 elderly residents (73.0 ± 7.8 years old) from rest homes and the community in Belo Horizonte, MG, Brazil. -174 G/C polymorphism was determined by direct sequencing of the product by PCR, and plasma IL-6 concentrations were measured by ELISA. Muscle strength in the knee joint was evaluated using a Biodex System 3 Pro® isokinetic dynamometer. ANCOVA was used to determine the effect of polymorphism on IL-6 levels and muscle strength, and the Pearson correlation coefficient to assess the relationship between IL-6 levels and muscle strength. -174 G/C polymorphism was associated with the plasma IL-6 levels of elderly women (P < 0.01) since homozygotes for the G allele showed high IL-6 levels (GG 3.85 pg/mL, GC + CC 2.13 pg/mL). There was no association of polymorphism on muscle strength (P > 0.05). No association was found between IL-6 levels and knee extensor muscle (r = 0.087, P = 0.306) or flexor (r = -0.011, P = 0.894) strength. An interaction between -174 G/C polymorphism and housing conditions of the sample of elderly women was identified, with the effect of genotype on IL-6 levels being higher in the institutionalized elderly. These results support the evidence that -174 G/C polymorphism of the IL6 gene associates with individual variability of plasma IL-6 levels in elderly women. | - |
Formato: dc.format | application/pdf | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Associação Brasileira de Divulgação Científica | - |
Direitos: dc.rights | Acesso Aberto | - |
Palavras-chave: dc.subject | Interleukin-6 | - |
Palavras-chave: dc.subject | Elderly | - |
Palavras-chave: dc.subject | Muscular strength | - |
Palavras-chave: dc.subject | 174 G/C polymorphism | - |
Título: dc.title | Effects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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