Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats

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Autor(es): dc.creatorSousa, Dircilei Nascimento de-
Autor(es): dc.creatorSantana, Washington Macedo de-
Autor(es): dc.creatorFerreira, Vania Maria Moraes-
Autor(es): dc.creatorDuarte, Wagner Rodrigues-
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Descrição: dc.descriptionPURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.-
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Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsActa Cirurgica Brasileira - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Acesso em: 26 nov. 2019.-
Palavras-chave: dc.subjectCognição-
Palavras-chave: dc.subjectComportamento-
Palavras-chave: dc.subjectSinvastatina-
Palavras-chave: dc.subjectOssos - regeneração-
Palavras-chave: dc.subjectRatos-
Título: dc.titleBehavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats-
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