Efficacy and pharmacokinetics of intravenous nanocapsule formulation of halofantrine in Plasmodium berghei-infected mice.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Autor(es): dc.creatorLoiseau, Philippe Marie Rene-
Autor(es): dc.creatorBories, Christian-
Autor(es): dc.creatorLegrand, Philippe-
Autor(es): dc.creatorDevissaguet, Jean-Philippe-
Autor(es): dc.creatorBarratt, Gillian-
Data de aceite: dc.date.accessioned2019-11-12T12:48:20Z-
Data de disponibilização: dc.date.available2019-11-12T12:48:20Z-
Data de envio: dc.date.issued2017-04-06-
Data de envio: dc.date.issued2017-04-06-
Data de envio: dc.date.issued2004-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7563-
Fonte completa do material: dc.identifierhttp://aac.asm.org/content/48/4/1222-
Fonte completa do material: dc.identifierhttps://doi.org/10.1128/AAC.48.4.1222-1228.2004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/559670-
Descrição: dc.descriptionThe efficacy and pharmacokinetics of a new parenteral formulation of halofantrine were studied in mice infected with Plasmodium berghei. The formulation consisted of nanocapsules with an oily core, prepared from either poly(D,L-lactide) (PLA) homopolymer or PLA that was surface modified with grafted polyethylene glycol chains. They were compared with a previously described intravenous halofantrine preparation. No toxic effects were observed with halofantrine in form of nanocapsules after intravenous administration for doses of up to 100 mg/kg, whereas the solubilized form in polyethylene glycol-dimethylacetamide was toxic at this dose. The halofantrine-loaded nanocapsules showed activity that was similar to or better than that of the solution in the 4-day test and as a single dose in severely infected mice, with only minimal differences between the two nanocapsule formulations. Halofantrine pharmacokinetics were determined in parallel with parasite development in severely infected mice. Nanocapsules increased the area under the curve for halofantrine in plasma more than sixfold compared with the solution throughout the experimental period of 70 h. Furthermore, nanocapsules induced a significantly faster control of parasite development than the solution in the first 48 h posttreatment. While the parasitemia fell more rapidly with PLA nanocapsules, the effect was more sustained with the surface-modified ones. This is consistent with surface-modified nanocapsules remaining longer in the circulation. These results suggest that nanocapsule formulations could provide a more favorable halofantrine profile in the plasma and reduce the intravenous dose necessary and therefore the toxicity, thus suggesting the use of halofantrine by a parenteral route in severe malaria.-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleEfficacy and pharmacokinetics of intravenous nanocapsule formulation of halofantrine in Plasmodium berghei-infected mice.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.