DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarneiro, Fernando Silva-
Autor(es): dc.creatorGiachini, Fernanda Regina Casagrande-
Autor(es): dc.creatorLima, Victor Vitorino-
Autor(es): dc.creatorCarneiro, Zidonia N.-
Autor(es): dc.creatorNunes, Kenia Pedrosa-
Autor(es): dc.creatorErgul, Adviye-
Autor(es): dc.creatorLeite, Romulo-
Autor(es): dc.creatorTostes, Rita de Cassia Aleixo-
Autor(es): dc.creatorWebb, Robert Clinton-
Data de aceite: dc.date.accessioned2019-11-12T12:48:19Z-
Data de disponibilização: dc.date.available2019-11-12T12:48:19Z-
Data de envio: dc.date.issued2017-04-06-
Data de envio: dc.date.issued2017-04-06-
Data de envio: dc.date.issued2008-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7562-
Fonte completa do material: dc.identifierhttps://www.nrcresearchpress.com/doi/10.1139/Y08-031#.Xclvj1VKjm4-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1139%2FY08-031-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/559669-
Descrição: dc.descriptionThe penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are enhanced in deoxycorticosterone acetate (DOCA)-salt mice and that blockade of ETA receptors prevents abnormal responses of the corpus cavernosum in DOCA-salt hypertension. Male C57BL/6 mice were unilaterally nephrectomized and treated for 5 weeks with both DOCA and water containing 1% NaCl and 0.2% KCl. Control mice were uninephrectomized and received tap water with no added salt. Animals received either the ETA antagonist atrasentan (5 mg·day−1·kg−1 body weight) or vehicle. DOCA-salt mice displayed increased systolic blood pressure (SBP), and treatment with atrasentan decreased SBP in DOCA-salt mice. Contractile responses in cavernosal strips from DOCA-salt mice were enhanced by ET-1, phenylephrine, and electrical field stimulation (EFS) of adrenergic nerves, whereas relaxations were not altered by IRL-1620 (an ETB agonist), acetylcholine, sodium nitroprusside, and EFS of nonadrenergic noncholinergic nerves. PD59089 (an ERK1/2 inhibitor), but not Y-27632 (a Rho-kinase inhibitor), abolished enhanced contractions to ET-1 in cavernosum from DOCA-salt mice. Treatment of DOCA-salt mice with atrasentan did not normalize cavernosal responses. In summary, DOCA-salt treatment in mice enhances cavernosal reactivity to contractile, but not to relaxant, stimuli, via ET-1/ETA receptor-independent mechanisms.-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectRho-kinase-
Palavras-chave: dc.subjectAtrasentan-
Título: dc.titleDOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum.-
Aparece nas coleções:Repositório Institucional - UFOP

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