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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Carneiro, Fernando Silva | - |
Autor(es): dc.creator | Giachini, Fernanda Regina Casagrande | - |
Autor(es): dc.creator | Lima, Victor Vitorino | - |
Autor(es): dc.creator | Carneiro, Zidonia N. | - |
Autor(es): dc.creator | Nunes, Kenia Pedrosa | - |
Autor(es): dc.creator | Ergul, Adviye | - |
Autor(es): dc.creator | Leite, Romulo | - |
Autor(es): dc.creator | Tostes, Rita de Cassia Aleixo | - |
Autor(es): dc.creator | Webb, Robert Clinton | - |
Data de aceite: dc.date.accessioned | 2019-11-12T12:48:19Z | - |
Data de disponibilização: dc.date.available | 2019-11-12T12:48:19Z | - |
Data de envio: dc.date.issued | 2017-04-06 | - |
Data de envio: dc.date.issued | 2017-04-06 | - |
Data de envio: dc.date.issued | 2008 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/7562 | - |
Fonte completa do material: dc.identifier | https://www.nrcresearchpress.com/doi/10.1139/Y08-031#.Xclvj1VKjm4 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1139%2FY08-031 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/559669 | - |
Descrição: dc.description | The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are enhanced in deoxycorticosterone acetate (DOCA)-salt mice and that blockade of ETA receptors prevents abnormal responses of the corpus cavernosum in DOCA-salt hypertension. Male C57BL/6 mice were unilaterally nephrectomized and treated for 5 weeks with both DOCA and water containing 1% NaCl and 0.2% KCl. Control mice were uninephrectomized and received tap water with no added salt. Animals received either the ETA antagonist atrasentan (5 mg·day−1·kg−1 body weight) or vehicle. DOCA-salt mice displayed increased systolic blood pressure (SBP), and treatment with atrasentan decreased SBP in DOCA-salt mice. Contractile responses in cavernosal strips from DOCA-salt mice were enhanced by ET-1, phenylephrine, and electrical field stimulation (EFS) of adrenergic nerves, whereas relaxations were not altered by IRL-1620 (an ETB agonist), acetylcholine, sodium nitroprusside, and EFS of nonadrenergic noncholinergic nerves. PD59089 (an ERK1/2 inhibitor), but not Y-27632 (a Rho-kinase inhibitor), abolished enhanced contractions to ET-1 in cavernosum from DOCA-salt mice. Treatment of DOCA-salt mice with atrasentan did not normalize cavernosal responses. In summary, DOCA-salt treatment in mice enhances cavernosal reactivity to contractile, but not to relaxant, stimuli, via ET-1/ETA receptor-independent mechanisms. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | restrito | - |
Palavras-chave: dc.subject | Rho-kinase | - |
Palavras-chave: dc.subject | Atrasentan | - |
Título: dc.title | DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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