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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Silva, Marco Aurélio Santos | - |
Autor(es): dc.creator | Nagato, Akinori Cardozo | - |
Autor(es): dc.creator | Trajano, Eduardo Tavares Lima | - |
Autor(es): dc.creator | Alves, Jackson Nogueira | - |
Autor(es): dc.creator | Bandeira, Ana Carla Balthar | - |
Autor(es): dc.creator | Porto, Luís Cristóvão | - |
Autor(es): dc.creator | Bezerra, Frank Silva | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:36:17Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:36:17Z | - |
Data de envio: dc.date.issued | 2016-05-13 | - |
Data de envio: dc.date.issued | 2016-05-13 | - |
Data de envio: dc.date.issued | 2013 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/6486 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/559193 | - |
Descrição: dc.description | Background: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop those diseases and others do not remain to be explained. Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to cigarette smoke. Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains were exposed to cigarette smoke (12 cigarettes/day), while their respective controls (n = 10) were exposed to ambient air for 60 days. After being euthanized, their heart was removed for biochemical analyses. Results: Although the malondialdehyde content did not increase in any of the groups, catalase activity decreased in the Swiss (p < 0.05) and BALB/c (p < 0.05) strain mice as compared with their respective control groups, while myeloperoxidase decreased in the C3H (p < 0.05) and C57BL/6 (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione content decreased in the Swiss, C3H, C57BL/6 (p < 0.05) and BALB/c (p < 0,001) strain mice as compared with their respective control groups. Regarding reduced glutathione content, an increase was observed in the Swiss strain mice (p < 0.05), while a decrease was observed in the C3H (p < 0.05) and BALB/c (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione/reduced glutathione ratio showed a reduction in the Swiss and C57BL/6 (p < 0.05) strain mice as compared with their respective control groups. Conclusion: The genetic background of mice can influence the antioxidant response after exposure to cigarette smoke and seems to be a determinant factor for redox imbalance in Swiss and C57BL/6 strain mice. Understanding antioxidant responses and genetic background of C3H and BALB/c strain mice might provide important information regarding cardiac resistance to cigarette smoke. (Arq Bras Cardiol. 2013;100(2):157-163) | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | aberto | - |
Direitos: dc.rights | Todo o conteúdo do periódico Arquivos Brasileiros de Cardiologia, exceto onde identificado, está licenciado sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: <http://www.scielo.br/scielo.php?script=sci_serial&pid=0066-782X&lng=en&nrm=iso>. Acesso em: 21 out. 2015. | - |
Palavras-chave: dc.subject | Oxidative stress | - |
Palavras-chave: dc.subject | Tobacco | - |
Palavras-chave: dc.subject | Smoke | - |
Palavras-chave: dc.subject | Mice | - |
Título: dc.title | The oxidative response of mouse hearts is modulated by genetic background. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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