The oxidative response of mouse hearts is modulated by genetic background.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Marco Aurélio Santos-
Autor(es): dc.creatorNagato, Akinori Cardozo-
Autor(es): dc.creatorTrajano, Eduardo Tavares Lima-
Autor(es): dc.creatorAlves, Jackson Nogueira-
Autor(es): dc.creatorBandeira, Ana Carla Balthar-
Autor(es): dc.creatorPorto, Luís Cristóvão-
Autor(es): dc.creatorBezerra, Frank Silva-
Data de aceite: dc.date.accessioned2019-11-06T13:36:17Z-
Data de disponibilização: dc.date.available2019-11-06T13:36:17Z-
Data de envio: dc.date.issued2016-05-13-
Data de envio: dc.date.issued2016-05-13-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/6486-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/559193-
Descrição: dc.descriptionBackground: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop those diseases and others do not remain to be explained. Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to cigarette smoke. Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains were exposed to cigarette smoke (12 cigarettes/day), while their respective controls (n = 10) were exposed to ambient air for 60 days. After being euthanized, their heart was removed for biochemical analyses. Results: Although the malondialdehyde content did not increase in any of the groups, catalase activity decreased in the Swiss (p < 0.05) and BALB/c (p < 0.05) strain mice as compared with their respective control groups, while myeloperoxidase decreased in the C3H (p < 0.05) and C57BL/6 (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione content decreased in the Swiss, C3H, C57BL/6 (p < 0.05) and BALB/c (p < 0,001) strain mice as compared with their respective control groups. Regarding reduced glutathione content, an increase was observed in the Swiss strain mice (p < 0.05), while a decrease was observed in the C3H (p < 0.05) and BALB/c (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione/reduced glutathione ratio showed a reduction in the Swiss and C57BL/6 (p < 0.05) strain mice as compared with their respective control groups. Conclusion: The genetic background of mice can influence the antioxidant response after exposure to cigarette smoke and seems to be a determinant factor for redox imbalance in Swiss and C57BL/6 strain mice. Understanding antioxidant responses and genetic background of C3H and BALB/c strain mice might provide important information regarding cardiac resistance to cigarette smoke. (Arq Bras Cardiol. 2013;100(2):157-163)-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsTodo o conteúdo do periódico Arquivos Brasileiros de Cardiologia, exceto onde identificado, está licenciado sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: <http://www.scielo.br/scielo.php?script=sci_serial&pid=0066-782X&lng=en&nrm=iso>. Acesso em: 21 out. 2015.-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectTobacco-
Palavras-chave: dc.subjectSmoke-
Palavras-chave: dc.subjectMice-
Título: dc.titleThe oxidative response of mouse hearts is modulated by genetic background.-
Aparece nas coleções:Repositório Institucional - UFOP

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