The role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Fernanda Cacilda dos Santos-
Autor(es): dc.creatorGuidine, Patrícia Alves Maia-
Autor(es): dc.creatorMachado, Natália Lima Santos-
Autor(es): dc.creatorXavier, Carlos Henrique-
Autor(es): dc.creatorMenezes, Rodrigo Cunha Alvim de-
Autor(es): dc.creatorSantos, Tasso Moraes-
Autor(es): dc.creatorMoraes, Márcio Flávio Dutra-
Autor(es): dc.creatorChianca Júnior, Deoclécio Alves-
Data de aceite: dc.date.accessioned2019-11-06T13:35:52Z-
Data de disponibilização: dc.date.available2019-11-06T13:35:52Z-
Data de envio: dc.date.issued2016-01-18-
Data de envio: dc.date.issued2016-01-18-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/6117-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/559023-
Descrição: dc.descriptionThe scorpion envenoming syndrome is an important worldwide public health problem due to its high incidence and potential severity of symptoms. Some studies address the high sensitivity of the central nervous system to this toxin action. It is known that cardiorespiratory manifestations involve the activation of the autonomic nervous system. However, the origin of this modulation remains unclear. Considering the important participation of the dorsomedial hypotalamus (DMH) in the cardiovascular responses during emergencial situations, the aim of this work is to investigate the involvement of the DMH on cardiovascular responses induced by intracerebroventricular (icv) injection of Tityustoxin (TsTX, a a-type toxin extracted from the Tityus serrulatus scorpion venom). Urethane-anaesthetized male Wistar rats (n = 30) were treated with PBS, muscimol or ionotropic glutamate receptor antagonists, bilaterally in DMH and later, with an icv injection of TsTX, or treated only with PBS in both regions. TsTX evoked a marked increase in mean arterial pressure and heart rate in all control rats. Interestingly, injection of muscimol, a GABAA receptor agonist, did not change the pressor and tachycardic responses evoked by TsTX. Remarkably, the injection ionotropic glutamate receptors antagonists in DMH abolished the pressor and the tachycardic response evoked by TsTX. Our data suggest that the central circuit recruited by TsTX, whose activation results in an array of physiological and behavioral alterations, depend on the activation of DMH ionotropic glutamate receptors. Moreover, our data provide new insights on the central mechanisms involved in the development of symptoms in the severe scorpion envenomation syndrome-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico NeuroToxicology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732991138094-
Palavras-chave: dc.subjectScorpion envenomation-
Palavras-chave: dc.subjectTityustoxin-
Palavras-chave: dc.subjectDorsomedial hypothalamus-
Palavras-chave: dc.subjectIonotropic glutamate receptor-
Palavras-chave: dc.subjectCardiovascular responses-
Título: dc.titleThe role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection.-
Aparece nas coleções:Repositório Institucional - UFOP

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