Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced by alfa 2-adrenergic activation in the lateral parabrachial nucleus.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAndrade, C. A. F.-
Autor(es): dc.creatorOliveira, Lisiane Brandino de-
Autor(es): dc.creatorFranzé, Gláucia Maria Fabrício de Andrade-
Autor(es): dc.creatorDe Luca Junior, L. A.-
Autor(es): dc.creatorColombari, Débora Simões de Almeida-
Autor(es): dc.creatorMenani, José Vanderlei-
Data de aceite: dc.date.accessioned2019-11-06T13:35:50Z-
Data de disponibilização: dc.date.available2019-11-06T13:35:50Z-
Data de envio: dc.date.issued2016-01-15-
Data de envio: dc.date.issued2016-01-15-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/6071-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/559008-
Descrição: dc.descriptionAlpha2-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined block-ade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by _2-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5–9/group) with cannulas implanted bilaterally in the LPBN were treated with the diuretic furosemide (10 mg/kg b wt.) combined with low dose of the angiotensin converting enzyme inhibitor captopril (5 mg/kg b wt.) subcutaneously. Bilat-eral injections of moxonidine (alpha2-adrenergic/imidazoline receptor agonist, 0.5 nmol) into the LPBN increased furosemide + captopril-induced 0.3 M NaCl intake (25.8 ± 1.4, vs. vehicle: 3.8 ± 1.1 ml/60 min). The opioidergic receptor antagonist naloxone (100 nmol) or the GABAA receptor antagonist bicuculline (5 nmol) injected into the LPBN partially reduced the increase of 0.3 M NaCl intake produced by LPBN moxonidine (11.8 ± 4.0 and 22.8 ± 4.5, respectively, vs. vehicle + moxonidine: 31.6 ± 4.0 ml/60 min, respectively). Similar to the treatment with each antagonist alone, the combined injections of nalox-one (100 nmol) and bicuculline (5 nmol) into the LPBN also partially reduced moxonidine effects on 0.3 M NaCl intake (15.5 ± 6.5 ml/60 min). The GABAB receptor antagonist saclofen (5 nmol) injected into the LPBN did not change the effects of moxonidine on 0.3 M NaCl intake (24.3 ± 7.8 ml/120 min). These results suggest that the increase of 0.3 M NaCl intake by _2-adrenergic receptor activation in the LPBN is partially dependent on GABAA and opioid receptor activation in this area.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Behavioural Brain Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732991263128-
Palavras-chave: dc.subjectSodium appetite-
Palavras-chave: dc.subjectOpioid-
Palavras-chave: dc.subjectThirst-
Título: dc.titleGabaergic and opioid receptors mediate the facilitation of NaCl intake induced by alfa 2-adrenergic activation in the lateral parabrachial nucleus.-
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