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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Andrade, C. A. F. | - |
Autor(es): dc.creator | Oliveira, Lisiane Brandino de | - |
Autor(es): dc.creator | Franzé, Gláucia Maria Fabrício de Andrade | - |
Autor(es): dc.creator | De Luca Junior, L. A. | - |
Autor(es): dc.creator | Colombari, Débora Simões de Almeida | - |
Autor(es): dc.creator | Menani, José Vanderlei | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:35:50Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:35:50Z | - |
Data de envio: dc.date.issued | 2016-01-15 | - |
Data de envio: dc.date.issued | 2016-01-15 | - |
Data de envio: dc.date.issued | 2015 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/6071 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/559008 | - |
Descrição: dc.description | Alpha2-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined block-ade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by _2-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5–9/group) with cannulas implanted bilaterally in the LPBN were treated with the diuretic furosemide (10 mg/kg b wt.) combined with low dose of the angiotensin converting enzyme inhibitor captopril (5 mg/kg b wt.) subcutaneously. Bilat-eral injections of moxonidine (alpha2-adrenergic/imidazoline receptor agonist, 0.5 nmol) into the LPBN increased furosemide + captopril-induced 0.3 M NaCl intake (25.8 ± 1.4, vs. vehicle: 3.8 ± 1.1 ml/60 min). The opioidergic receptor antagonist naloxone (100 nmol) or the GABAA receptor antagonist bicuculline (5 nmol) injected into the LPBN partially reduced the increase of 0.3 M NaCl intake produced by LPBN moxonidine (11.8 ± 4.0 and 22.8 ± 4.5, respectively, vs. vehicle + moxonidine: 31.6 ± 4.0 ml/60 min, respectively). Similar to the treatment with each antagonist alone, the combined injections of nalox-one (100 nmol) and bicuculline (5 nmol) into the LPBN also partially reduced moxonidine effects on 0.3 M NaCl intake (15.5 ± 6.5 ml/60 min). The GABAB receptor antagonist saclofen (5 nmol) injected into the LPBN did not change the effects of moxonidine on 0.3 M NaCl intake (24.3 ± 7.8 ml/120 min). These results suggest that the increase of 0.3 M NaCl intake by _2-adrenergic receptor activation in the LPBN is partially dependent on GABAA and opioid receptor activation in this area. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O Periódico Behavioural Brain Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732991263128 | - |
Palavras-chave: dc.subject | Sodium appetite | - |
Palavras-chave: dc.subject | Opioid | - |
Palavras-chave: dc.subject | Thirst | - |
Título: dc.title | Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced by alfa 2-adrenergic activation in the lateral parabrachial nucleus. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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