Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorToledo, Juliana Oliveira-
Autor(es): dc.creatorMoraes, Clayton Franco-
Autor(es): dc.creatorSouza, Vinícius Carolino-
Autor(es): dc.creatorFurioso, Audrey Cecília Tonet-
Autor(es): dc.creatorAfonso, Luis Carlos Crocco-
Autor(es): dc.creatorCórdova, Cláudio-
Autor(es): dc.creatorNóbrega, Otávio Toledo-
Data de aceite: dc.date.accessioned2019-11-06T13:35:48Z-
Data de disponibilização: dc.date.available2019-11-06T13:35:48Z-
Data de envio: dc.date.issued2016-01-21-
Data de envio: dc.date.issued2016-01-21-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/6178-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/558993-
Descrição: dc.descriptionObjective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control. Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention. Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P0.01) at the endpoint compared with baseline, whereas the mean INF-γ level was not significantly different from baseline values. In separate analyses, only users of antagonists of the renin–angiotensin system and users of diuretics exhibited the same significant treatment-induced reduction in serum IL-6 and TNF-α observed in the whole group. Conclusion: Our data demonstrates that a clinically guided antihypertensive treatment is effective in reversing the low-grade proinflammatory state of serum cytokines found in post¬menopausal women and support extracardiac benefits from diuretics and renin–angiotensin system antagonists-
Idioma: dc.languagept_BR-
Direitos: dc.rightsThis work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited. Fonte: Clinical Interventions in Aging<https://www.dovepress.com/tailored-antihypertensive-drug-therapy-prescribed-to-older-women-atten-peer-reviewed-article-CIA>. Acesso em: 15 out 2015.-
Palavras-chave: dc.subjectRenin–angiotensin system-
Palavras-chave: dc.subjectHypertension-
Título: dc.titleTailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α.-
Aparece nas coleções:Repositório Institucional - UFOP

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