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Metadados | Descrição | Idioma |
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Autor(es): dc.creator | Toledo, Juliana Oliveira | - |
Autor(es): dc.creator | Moraes, Clayton Franco | - |
Autor(es): dc.creator | Souza, Vinícius Carolino | - |
Autor(es): dc.creator | Furioso, Audrey Cecília Tonet | - |
Autor(es): dc.creator | Afonso, Luis Carlos Crocco | - |
Autor(es): dc.creator | Córdova, Cláudio | - |
Autor(es): dc.creator | Nóbrega, Otávio Toledo | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:35:48Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:35:48Z | - |
Data de envio: dc.date.issued | 2016-01-21 | - |
Data de envio: dc.date.issued | 2016-01-21 | - |
Data de envio: dc.date.issued | 2015 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/6178 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/558993 | - |
Descrição: dc.description | Objective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control. Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention. Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P0.01) at the endpoint compared with baseline, whereas the mean INF-γ level was not significantly different from baseline values. In separate analyses, only users of antagonists of the renin–angiotensin system and users of diuretics exhibited the same significant treatment-induced reduction in serum IL-6 and TNF-α observed in the whole group. Conclusion: Our data demonstrates that a clinically guided antihypertensive treatment is effective in reversing the low-grade proinflammatory state of serum cytokines found in post¬menopausal women and support extracardiac benefits from diuretics and renin–angiotensin system antagonists | - |
Idioma: dc.language | pt_BR | - |
Direitos: dc.rights | This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited. Fonte: Clinical Interventions in Aging<https://www.dovepress.com/tailored-antihypertensive-drug-therapy-prescribed-to-older-women-atten-peer-reviewed-article-CIA>. Acesso em: 15 out 2015. | - |
Palavras-chave: dc.subject | Renin–angiotensin system | - |
Palavras-chave: dc.subject | Hypertension | - |
Título: dc.title | Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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