Leishmania braziliensis : partial control of experimental infection by interleukin-12 p40 deficient mice.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza Neto, Sebastião Martins de-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorVieira, Leda Quercia-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Data de aceite: dc.date.accessioned2019-11-06T13:35:21Z-
Data de disponibilização: dc.date.available2019-11-06T13:35:21Z-
Data de envio: dc.date.issued2015-12-07-
Data de envio: dc.date.issued2015-12-07-
Data de envio: dc.date.issued2004-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/5915-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/558801-
Descrição: dc.descriptionResistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-γ) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN-γ-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN-γ suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL- 12p40 -/- infected with L. braziliensis.-
Idioma: dc.languageen-
Direitos: dc.rightsTodo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz , exceto onde identificado, está licenciado sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: <http://www.scielo.br/scielo.php/script_sci_serial/pid_0074-0276/lng_pt/nrm_iso>. Acesso em: 21 out. 2015.-
Palavras-chave: dc.subjectCutaneous leishmaniasis-
Título: dc.titleLeishmania braziliensis : partial control of experimental infection by interleukin-12 p40 deficient mice.-
Aparece nas coleções:Repositório Institucional - UFOP

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