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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Cleto, L. S. | - |
Autor(es): dc.creator | Oleto, A. F. | - |
Autor(es): dc.creator | Sousa, L. P. | - |
Autor(es): dc.creator | Barreto, T. O. | - |
Autor(es): dc.creator | Cruz, Jader dos Santos | - |
Autor(es): dc.creator | Penaforte, Claudia Lopes | - |
Autor(es): dc.creator | Magalhães, J. C. | - |
Autor(es): dc.creator | Franco, J. Sousa | - |
Autor(es): dc.creator | Pinto, Kelerson Mauro de Castro | - |
Autor(es): dc.creator | Azevedo, Ana Carolina Campi | - |
Autor(es): dc.creator | Vieira, Etel Rocha | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:34:06Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:34:06Z | - |
Data de envio: dc.date.issued | 2015-09-22 | - |
Data de envio: dc.date.issued | 2015-09-22 | - |
Data de envio: dc.date.issued | 2011 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/5644 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/558276 | - |
Descrição: dc.description | Our objective was to determine lipid peroxidation and nuclear factor-κB (NF-κB) activation in skeletal muscle and the plasma cytokine profile following maximum progressive swimming. Adult male Swiss mice (N = 15) adapted to the aquatic environment were randomly divided into three groups: immediately after exercise (EX1), 3 h after exercise (EX2) and control. Animals from the exercising groups swam until exhaustion, with an initial workload of 2% of body mass attached to the tail. Control mice did not perform any exercise but were kept immersed in water for 20 min. Maximum swimming led to reactive oxygen species (ROS) generation in skeletal muscle, as indicated by increased thiobarbituric acid reactive species (TBARS) levels (4062.67 ± 1487.10 vs 19,072.48 ± 8738.16 nmol malondialdehyde (MDA)/mg protein, control vs EX1). Exercise also promoted NF-κB activation in soleus muscle. Cytokine secretion following exercise was marked by increased plasma interleukin-6 (IL-6) levels 3 h post-exercise (P < 0.05). Interleukin-10 (IL-10) levels were reduced following exercise and remained reduced 3 h post-exercise (P < 0.05). Plasma levels of other cytokines investigated, monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin-12 (IL-12), were not altered by exercise. The present findings showed that maximum swimming, as well as other exercise models, led to lipid peroxidation and NF-κB activation in skeletal muscle and increased plasma IL-6 levels. The plasma cytokine response was also marked by reduced IL-10 levels. These results were attributed to exercise type and intensity. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | No permission is required from the authors or the publishers download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. Fonte: Brazilian Journal of Medical and Biological Research <http://www.bjournal.com.br/index.php?option=com_content&view=article&id=185&Itemid=139>. Acesso em: 21 jan. 2014. | - |
Palavras-chave: dc.subject | Swimming | - |
Palavras-chave: dc.subject | Interleukin-6 | - |
Palavras-chave: dc.subject | Interleukin-10 | - |
Palavras-chave: dc.subject | Thiobarbituric acid reactive species | - |
Palavras-chave: dc.subject | Cytokine | - |
Título: dc.title | Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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