Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorGil, Laurent Frédéric-
Autor(es): dc.creatorHan, Yongxin-
Autor(es): dc.creatorOpas, Evan E.-
Autor(es): dc.creatorRodan, Gideon A.-
Autor(es): dc.creatorRuel, Réjean-
Data de aceite: dc.date.accessioned2019-11-06T13:33:46Z-
Data de disponibilização: dc.date.available2019-11-06T13:33:46Z-
Data de envio: dc.date.issued2015-04-17-
Data de envio: dc.date.issued2015-04-17-
Data de envio: dc.date.issued1999-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/5121-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/558128-
Descrição: dc.descriptionConjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked con- jugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3581981508139.-
Palavras-chave: dc.subjectOsteoporosis-
Palavras-chave: dc.subjectProstaglandin E2-
Palavras-chave: dc.subjectBisphosphonate-
Palavras-chave: dc.subjectAlendronate-
Palavras-chave: dc.subjectConjugate-
Título: dc.titleProstaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.