Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorTullet, Jennifer M. A.-
Autor(es): dc.creatorHertweck, Maren-
Autor(es): dc.creatorAn, Jae Hyung-
Autor(es): dc.creatorBaker, Joseph-
Autor(es): dc.creatorHwang, Ji Yun-
Autor(es): dc.creatorLiu, Shu-
Autor(es): dc.creatorOliveira, Riva de Paula-
Autor(es): dc.creatorBaumeister, Ralf-
Autor(es): dc.creatorBlackwell, T. Keith-
Data de aceite: dc.date.accessioned2019-11-06T13:33:06Z-
Data de disponibilização: dc.date.available2019-11-06T13:33:06Z-
Data de envio: dc.date.issued2015-03-31-
Data de envio: dc.date.issued2015-03-31-
Data de envio: dc.date.issued2008-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4847-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557871-
Descrição: dc.descriptionInsulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IISinhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends against oxidative stress bymobilizing the conserved phase 2 detoxification response. Herewe showthat IIS not only opposes DAF-16 but also directly inhibits SKN-1 in parallel. The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and reduced IIS leads to constitutive SKN-1 nuclear accumulation in the intestine and SKN-1 target gene activation. SKN-1 contributes to the increased stress tolerance and longevity resulting from reduced IIS and delays aging when expressed transgenically. Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Cell concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3493711392245.-
Título: dc.titleDirect inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.-
Aparece nas coleções:Repositório Institucional - UFOP

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