Vitamin D overload and experimental Trypanosoma cruzi infection: parasitological and histopathological aspects.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Marcelo Eustáquio-
Autor(es): dc.creatorSilva, Marcílio Eustáquio de Castro-
Autor(es): dc.creatorNicoli, Jacques Robert-
Autor(es): dc.creatorBambirra, Eduardo Alves-
Autor(es): dc.creatorVieira, Enio Carlos-
Data de aceite: dc.date.accessioned2019-11-06T13:33:01Z-
Data de disponibilização: dc.date.available2019-11-06T13:33:01Z-
Data de envio: dc.date.issued2015-03-25-
Data de envio: dc.date.issued2015-03-25-
Data de envio: dc.date.issued1993-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4742-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557831-
Descrição: dc.descriptionl. Six groups of 45-day-old, 23.0 & 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LDm was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577160156339.-
Palavras-chave: dc.subjectVitamin D-
Título: dc.titleVitamin D overload and experimental Trypanosoma cruzi infection: parasitological and histopathological aspects.-
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