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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Rodrigues, Fabiana Aparecida | - |
Autor(es): dc.creator | Chianca Júnior, Deoclécio Alves | - |
Autor(es): dc.creator | Fernandes, Luciano Gonçalves | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:32:47Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:32:47Z | - |
Data de envio: dc.date.issued | 2015-03-16 | - |
Data de envio: dc.date.issued | 2015-03-16 | - |
Data de envio: dc.date.issued | 2012 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/4649 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/557732 | - |
Descrição: dc.description | Post-weaning protein malnutrition is often related to the development of cardiovascular and metabolic diseases in humans, as well to changed content of neurotransmitters in the central nervous system under experimental conditions. The rostral ventrolateral medulla (RVLM) is a bulbar region that contains sympathetic premotor neurons; the excitatory amino acid L-glutamate seems to be the main neurotransmitter at this level. The aim of the present study was to evaluate the possible change in the L-glutamate sensitivity of the RVLM neurons of malnourished animals. Male Fischer rats were divided into two groups: control (n = 15) and malnourished (n = 19). Four days before the experiments, guide cannulas were implanted bilaterally in direction of the RVLM for microinjection of L-glutamate. Twenty-four hours before the experiments, the femoral artery was cannulated for cardiovascular recordings. The results showed that the baseline heart rate increased in malnourished compared to control animals (412.18 ± 16.03 bpm vs. 370.74 ± 9.59 bpm, respectively). Malnourished animals presented a dissimilar concentration-dependent pressor response curve to L-glutamate and an attenuated barorefl ex gain. Our results suggest that post-weaning protein restriction aff ects glutamatergic neurotransmission of the barorefl ex at the RVLM level. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | Authors of articles published in Biological Research are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement. Fonte: Biological Research < http://www.biolres.com/about> Acesso em: 26 jan. 2015. | - |
Palavras-chave: dc.subject | Baroreflex | - |
Palavras-chave: dc.subject | Blood pressure | - |
Palavras-chave: dc.subject | Heart rate | - |
Palavras-chave: dc.subject | Malnutrition | - |
Palavras-chave: dc.subject | Glutamate receptors | - |
Título: dc.title | Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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