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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Dornas, Waleska Claudia Amaral | - |
Autor(es): dc.creator | Lima, Wanderson Geraldo de | - |
Autor(es): dc.creator | Santos, Rinaldo Cardoso dos | - |
Autor(es): dc.creator | Souza, Melina Oliveira de | - |
Autor(es): dc.creator | Silva, Maísa | - |
Autor(es): dc.creator | Diniz, Mirla Fiuza | - |
Autor(es): dc.creator | Silva, Marcelo Eustáquio | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:32:45Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:32:45Z | - |
Data de envio: dc.date.issued | 2015-03-13 | - |
Data de envio: dc.date.issued | 2015-03-13 | - |
Data de envio: dc.date.issued | 2012 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/4626 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/557719 | - |
Descrição: dc.description | Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and drinking water throughout the study; high fructose (HF), which received a normal salt diet and 20% fructose supplemented drinking water. After 10 weeks, half of the animals from HF group were randomly switched to a high-salt diet and 20% fructose supplemented drinking water (HFS) for more 10 weeks. Serum PON1 activity was determined by synthetic substrate phenyl acetate. HFS rats showed markedly decreased PON1 activity (HFS rats, 44.3 ± 14.4 g/dL versus CON rats, 64.4 ± 13.3 g/dL, P<0.05) as compared to controls. In parallel, the level of oxidative stress, as indicated by thiobarbituric acid reactive substances (TBARS), was increased in HFS rats by 1.2-fold in the liver in relation to controls and was negatively correlated with PON activity. Differential leukocyte counts in blood showed a significant change in lymphocytes and monocytes profile. In conclusion, these results show that PON1 activity is decreased in fructose-fed insulin-resistant rats on a high-salt diet, which may be associated with increased oxidative stress, leading to inflammation. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Nutrition & Metabolism. Acesso em: 14 jan. 2014. | - |
Palavras-chave: dc.subject | Fructose fed rats | - |
Palavras-chave: dc.subject | High salt diet | - |
Palavras-chave: dc.subject | Paraoxonase | - |
Palavras-chave: dc.subject | Atherosclerosis | - |
Título: dc.title | Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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