Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorDornas, Waleska Claudia Amaral-
Autor(es): dc.creatorLima, Wanderson Geraldo de-
Autor(es): dc.creatorSantos, Rinaldo Cardoso dos-
Autor(es): dc.creatorSouza, Melina Oliveira de-
Autor(es): dc.creatorSilva, Maísa-
Autor(es): dc.creatorDiniz, Mirla Fiuza-
Autor(es): dc.creatorSilva, Marcelo Eustáquio-
Data de aceite: dc.date.accessioned2019-11-06T13:32:45Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:45Z-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4626-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557719-
Descrição: dc.descriptionParaoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and drinking water throughout the study; high fructose (HF), which received a normal salt diet and 20% fructose supplemented drinking water. After 10 weeks, half of the animals from HF group were randomly switched to a high-salt diet and 20% fructose supplemented drinking water (HFS) for more 10 weeks. Serum PON1 activity was determined by synthetic substrate phenyl acetate. HFS rats showed markedly decreased PON1 activity (HFS rats, 44.3 ± 14.4 g/dL versus CON rats, 64.4 ± 13.3 g/dL, P<0.05) as compared to controls. In parallel, the level of oxidative stress, as indicated by thiobarbituric acid reactive substances (TBARS), was increased in HFS rats by 1.2-fold in the liver in relation to controls and was negatively correlated with PON activity. Differential leukocyte counts in blood showed a significant change in lymphocytes and monocytes profile. In conclusion, these results show that PON1 activity is decreased in fructose-fed insulin-resistant rats on a high-salt diet, which may be associated with increased oxidative stress, leading to inflammation.-
Idioma: dc.languageen-
Direitos: dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Nutrition & Metabolism. Acesso em: 14 jan. 2014.-
Palavras-chave: dc.subjectFructose fed rats-
Palavras-chave: dc.subjectHigh salt diet-
Palavras-chave: dc.subjectParaoxonase-
Palavras-chave: dc.subjectAtherosclerosis-
Título: dc.titleSalt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity.-
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