Neuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRocha, Alexandro Aluisio-
Autor(es): dc.creatorSá, Renata Guerra-
Autor(es): dc.creatorSilveira, Nusa de Almeida-
Autor(es): dc.creatorFranci, Janete Aparecida Anselmo-
Autor(es): dc.creatorFranci, Celso Rodrigues-
Data de aceite: dc.date.accessioned2019-11-06T13:32:38Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:38Z-
Data de envio: dc.date.issued2015-04-01-
Data de envio: dc.date.issued2015-04-01-
Data de envio: dc.date.issued2006-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4927-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557679-
Descrição: dc.descriptionThe multiple control of gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) secretion involves locus coeruleus (LC) and neuropeptide Y (NPY). The objective of the present study was to analyze the possible contribution of the LC to the control of NPY activity in the medial basal hypothalamus (MBH) and medial preoptic area (MPOA) during the LH surge induced by estrogen (E2) and progesterone (P4). Ovariectomized adult Wistar rats were submitted to the hormone replacement and to the LC bilateral lesion (lesioned groups) or sham surgery (control groups). On the day of the experiment the rats were decapitated at 11:00, 13:00, 15:00 and 17:00 h for plasma and brain collection. Plasma LH was determined by radioimmunoassay. MBH and MPOA were microdissected for the measurement of NPY by enzyme immunoassay. NPY mRNA levels in MBH were assessed by the ribonuclease protection assay. The results showed that LC lesion: decreased the plasma LH; increased the content of NPY in the MBH and reduced the increase of NPY content in the MPOA during afternoon in which LH surge was induced. The increased NPY content in MBH was not associated with an increase of the respective mRNA content, suggesting the action of postranscriptional and/or posttranslational mechanisms. In conclusion, the NPY activity in the MPOA on LH surge induced by estrogen and progesterone could be controlled by LC through two ways, at least: one direct way, by the release of NPY from LC neurons terminals that innervate the MPOA and they release NA and NPY; one indirect way, by the control of release but not synthesis of NPY from neurons in the MBH which innervate the MPOA.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Neuropeptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120362267.-
Palavras-chave: dc.subjectLocus coeruleus-
Palavras-chave: dc.subjectNeuropeptide-
Palavras-chave: dc.subjectNeuropeptide-
Palavras-chave: dc.subjectLuteinizing hormone-
Palavras-chave: dc.subjectMedial preoptic area-
Título: dc.titleNeuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus.-
Aparece nas coleções:Repositório Institucional - UFOP

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