Coxsackievirus B5 induced apoptosis of HeLa cells: effects on p53 and SUMO.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorGomes, Rogério-
Autor(es): dc.creatorSá, Renata Guerra-
Autor(es): dc.creatorArruda, Eurico-
Data de aceite: dc.date.accessioned2019-11-06T13:32:38Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:38Z-
Data de envio: dc.date.issued2015-04-01-
Data de envio: dc.date.issued2015-04-01-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4932-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557676-
Descrição: dc.descriptionCoxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of the CVB5-infected cell has a pivotal role in this process. We have investigated the CVB5-induced apoptosis of HeLa cells and found that it happens by the intrinsic pathway by a mechanism dependent on the ubiquitin–proteasome system, associated with nuclear aggregation of p53. Striking redistribution of both SUMO and UBC9 was noted at 4 h post-infection, simultaneously with a reduction in the levels of the ubiquitin-ligase HDM2. Taken together, these results suggest that CVB5 infection of HeLa cells elicit the intrinsic pathway of apoptosis by MDM2 degradation and p53 activation, destabilizing protein sumoylation, by a mechanism that is dependent on a functional ubiquitin–proteasome system.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Virology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120273893.-
Palavras-chave: dc.subjectCoxsackievirus B5-
Palavras-chave: dc.subjectSUMO-
Palavras-chave: dc.subjectApoptosis-
Título: dc.titleCoxsackievirus B5 induced apoptosis of HeLa cells: effects on p53 and SUMO.-
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