Humoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorVital, Wendel Coura-
Autor(es): dc.creatorMarques, M. J.-
Autor(es): dc.creatorGiunchetti, Rodolfo Cordeiro-
Autor(es): dc.creatorCarvalho, A. Teixeira-
Autor(es): dc.creatorMoreira, Nádia das Dores-
Autor(es): dc.creatorSouza, Juliana Vitoriano de-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorOliveira, Rodrigo Corrêa de-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Autor(es): dc.creatorCarneiro, Mariângela-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Data de aceite: dc.date.accessioned2019-11-06T13:32:37Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:37Z-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4627-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557669-
Descrição: dc.descriptionMolecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar to those of CD, including isotype profiles and concentrations of monocytes. Similar biomarkers were found in AD-II and SD, such as, higher levels of immunoglobulins IgG, IgG2, IgM and IgA and higher concentrations of eosinophils. High frequencies of T lymphocytes and CD4+ T cells were observed in both AD-I and AD-II compared to SD, whereas CD8+ T cells were higher only in AD-II compared with SD. Analysis of B lymphocytes revealed an increased frequency of this cell type only in AD-II animals compared with SD. Asymptomatic dogs appear to have a dichotomous infection spectrum that can influence the humoral and cellular immunological status during canine visceral leishmaniasis.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico The Veterinary Journal concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120087801.-
Palavras-chave: dc.subjectCanine visceral leishmaniasis-
Palavras-chave: dc.subjectAsymptomatic dogs-
Palavras-chave: dc.subjectImmune response-
Título: dc.titleHumoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection.-
Aparece nas coleções:Repositório Institucional - UFOP

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