Infection with Leishmania major induces interleukin-12 production in vivo.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorVieira, Leda Quercia-
Autor(es): dc.creatorHondowicz, Brian D.-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Autor(es): dc.creatorWysocka, Maria-
Autor(es): dc.creatorTrinchieri, Giorgio-
Autor(es): dc.creatorScott, Phillip-
Data de aceite: dc.date.accessioned2019-11-06T13:32:32Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:32Z-
Data de envio: dc.date.issued2015-03-12-
Data de envio: dc.date.issued2015-03-12-
Data de envio: dc.date.issued1994-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4619-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557631-
Descrição: dc.descriptionExperimental infections of mice with the protozoan parasite Leishmania major provide an excellent model for defining the conditions required for generation of CD4 ÷ Thl and Th2 cells in vivo. Since interleukin-12 (IL-12) has been implicated in the development of Thl cells, we investigated whether L. major stimulates IL-12 production in vitro or in vivo. Surprisingly, macrophages cultured in vitro failed to produce IL-12 following L. major infection. In contrast, lymph node cells from C3H mice infected for 2 days with L. major produced elevated levels of IL-12. In order to determine if the inability to stimulate IL-12 production was limited to in vitro infections, we infected macrophages in vivo by inoculating L. major into the peritoneal cavity. Peritoneal cells isolated 24 h later exhibited a significant increase in the number of cells producing IL-12. In addition, supernatants harvested from these cells following culture contained elevated levels of IL-12. These data indicate that L. major infection induces increased IL-12 production in mice.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Immunology Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901220850.-
Título: dc.titleInfection with Leishmania major induces interleukin-12 production in vivo.-
Aparece nas coleções:Repositório Institucional - UFOP

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