Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorNabors, Gary S.-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Autor(es): dc.creatorFarrell, Jay P.-
Autor(es): dc.creatorScott, Phillip-
Data de aceite: dc.date.accessioned2019-11-06T13:32:31Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:31Z-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued2015-03-13-
Data de envio: dc.date.issued1995-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4631-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557630-
Descrição: dc.descriptionSuccessful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Thi and Th2 cells, the requirements for switching an established response are not understood. Here we use infection with Leishmania major as a model to investigate those requirements. We report that treatment with interleukin 12 (IL-12), in combination with the antimony-based leishmanicidal drug Pentostam, induces healing in L. major-infected mice and that healing is associated with a switch from a Th2 to a Thl response. The data suggest that decreasing antigen levels may be required for IL-12 to inhibit a Th2 response and enhance a Thi response. These observations are important for treatment of nonhealing forms of human leishmaniasis and also demonstrate that in a chronic infectious disease an inappropriate Th2 response can be switched to an effective Thi response.-
Idioma: dc.languageen-
Direitos: dc.rightsBeginning with articles submitted in Volume 106 (2009) the author(s) retains copyright to individual articles published in PNAS. Fonte: Journal PNAS. Acesso em: 05 dez. 2014.-
Palavras-chave: dc.subjectAntimony-
Palavras-chave: dc.subjectChronic infection-
Título: dc.titleSwitch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.-
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