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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Ribeiro, Antônio Luiz Pinho | - |
Autor(es): dc.creator | Teixeira, Mauro Martins | - |
Autor(es): dc.creator | Reis, Adelina Martha dos | - |
Autor(es): dc.creator | Talvani, André | - |
Autor(es): dc.creator | Perez, Amanda Arantes | - |
Autor(es): dc.creator | Barros, Márcio Vinicius Lins | - |
Autor(es): dc.creator | Rocha, Manoel Otávio da Costa | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:31:34Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:31:34Z | - |
Data de envio: dc.date.issued | 2015-01-21 | - |
Data de envio: dc.date.issued | 2015-01-21 | - |
Data de envio: dc.date.issued | 2006 | - |
Fonte completa do material: dc.identifier | http://www.repositorio.ufop.br/handle/123456789/4304 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/557231 | - |
Descrição: dc.description | Background: Left ventricular dysfunction (LVd) is the main predictor of mortality in Chagas disease (ChD). Aims: To compare the diagnostic performance of the conventional approach (ECG and chest X-ray) in the recognition of LVd in ChD, with a new strategy, in which BNP is measured in patients with an abnormal ECG. Methods: Consecutive ChD patients recruited at an Outpatient Reference Center in Belo Horizonte, Brazil, without other systemic diseases, in 1998–99 (sample 1, n =165) and in 2001–02 (sample 2, n =62) underwent ECG, chest X-ray, BNP measurement and echocardiography. Results: The prevalence of LVd (ejection fraction _0.40) was 9.1% in the sample 1. The conventional strategy recognized all patients with LVd (sensitivity: 100%, 95% CI: 79.6–100% and negative predictive value _PV 100%, 92.1–100%), but with low specificity (30%, 95% CI: 23.2–37.8) and +PV (12.5%, 95% IC: I7.7–19.6). The BNP/ECG strategy showed significantly better specificity (96.0%, 95% CI: 91.5–98.2, p <0.001) and +PV (66.7%, 95% CI: 43.7–83.7, p <0.001), and non-significantly lower sensitivity (80.0%, 95% CI: 54.8–93.0, p =0.25) and _PV (98.0%,95% CI: 94.2–99.3, p =0.08). Overall accuracy was improved with the new strategy. (94.5%,95% CI: 90.0– 97.1_36.4%, 95% CI: 29.4–43.9, p <0.001). Similar results were obtained for the sample 2. Conclusions: The BNP-based strategy was more accurate than the conventional approach in the detection of LVd in ChD patients and should be considered as a valid option. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O Periódico International Journal of Cardiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3517810848422. | - |
Palavras-chave: dc.subject | Natriuretic peptides | - |
Palavras-chave: dc.subject | Cardiomyopathy | - |
Palavras-chave: dc.subject | Diagnosis | - |
Palavras-chave: dc.subject | Ventricles | - |
Palavras-chave: dc.subject | Chagas disease | - |
Título: dc.title | Brain natriuretic peptide based strategy to detect left ventricular dysfunction in Chagas disease: a comparison with the conventional approach. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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