Successful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorVilela, Márcia de Carvalho-
Autor(es): dc.creatorGomes, Daniel Cláudio de Oliveira-
Autor(es): dc.creatorSilva, Eduardo de Almeida Marques da-
Autor(es): dc.creatorSerafim, Tiago Donatelli-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Autor(es): dc.creatorRezende, Simone Aparecida-
Data de aceite: dc.date.accessioned2019-11-06T13:31:22Z-
Data de disponibilização: dc.date.available2019-11-06T13:31:22Z-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4007-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557146-
Descrição: dc.descriptionThis study evaluated the potential of a Leishmania antigen vaccine in protecting BALB/c mice against Leishmania chagasi. Mice received two subcutaneous doses of L. amazonensis vaccine with Corynebacterium parvum and subsequent boost was done without adjuvant. One week later, mice were challenged with L. chagasi. We observed that this vaccine caused a significant reduction in parasite load in liver and spleen and induced a high production of IFN-_ and IL-4 by spleen cells from vaccinated mice in response to Leishmania antigen. Together, our data show that this vaccine is capable of inducing a Th1/Th2 response that is important to control parasite replication.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890151852.-
Palavras-chave: dc.subjectVaccine-
Palavras-chave: dc.subjectLeishmania chagasi-
Título: dc.titleSuccessful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum.-
Aparece nas coleções:Repositório Institucional - UFOP

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