Molecular and biological characterization of Trypanosoma cruzi strains isolated from children from Jequitinhonha Valley, State of Minas Gerais, Brazil.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Jaquelline Carla Valamiel de Oliveira e-
Autor(es): dc.creatorAssis, Girley Francisco Machado de-
Autor(es): dc.creatorOliveira, Maykon Tavares de-
Autor(es): dc.creatorValadares, Helder Magno Silva-
Autor(es): dc.creatorValle, Ítalo Faria do-
Autor(es): dc.creatorPaiva, Nívia Carolina Nogueira de-
Autor(es): dc.creatorMartins, Helen Rodrigues-
Autor(es): dc.creatorLana, Marta de-
Data de aceite: dc.date.accessioned2019-11-06T13:31:21Z-
Data de disponibilização: dc.date.available2019-11-06T13:31:21Z-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/3998-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557141-
Descrição: dc.descriptionThe biological diversity of Trypanosoma cruzi strains plays an important role in the clinical and epidemiological features of Chagas disease. Methods: Eight T. cruzi strains isolated from children living in a Chagas disease vector-controlled area of Jequitinhonha Valley, State of Minas Gerais, Brazil, were genetically and biologically characterized. Results: The characterizations demonstrated that all of the strains belonged to T. cruzi II, and showed high infectivity and a variable mean maximum peak of parasitemia. Six strains displayed low parasitemia, and two displayed moderate parasitemia. Later peaks of parasitemia and a predominance of intermediate and large trypomastigotes in all T. cruzi strains were observed. The mean prepatent period was relatively short (4.2±0.25 to 13.7±3.08 days), whereas the patent period ranged from 3.3±1.08 to 34.5±3.52 days. Mortality was observed only in animals infected with strain 806 (62.5%). Histopathological analysis of the heart showed that strains 501 and 806 caused infl ammation, but fi brosis was observed only in animals infected with strain 806. Conclusions: The results indicate the presence of an association between the biological behavior in mice and the genetic characteristics of the parasites. The study also confi rmed general data from Brazil where T. cruzi II lineage is the most prevalent in the domiciliary cycle and generally has low virulence, with some strains capable of inducing infl ammatory processes and fi brosis.-
Idioma: dc.languageen-
Direitos: dc.rightsPermite distribuição da obra sob uma licença idêntica a do Editor. Permite o armazenamento das versões pré-print e pós-print. Fonte Diadorim <http://diadorim.ibict.br/handle/1/127>.Acesso em: 01 ago. 2014.-
Palavras-chave: dc.subjectTrypanosoma cruzi strains-
Palavras-chave: dc.subjectJequitinhonha Valley-
Palavras-chave: dc.subjectMolecular characterization-
Palavras-chave: dc.subjectBiological characterization-
Título: dc.titleMolecular and biological characterization of Trypanosoma cruzi strains isolated from children from Jequitinhonha Valley, State of Minas Gerais, Brazil.-
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