Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN- and cytolytic activity by CD8+ T cells.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorResende, Daniela de Melo-
Autor(es): dc.creatorCaetano, Bráulia Costa-
Autor(es): dc.creatorDutra, Míriam Santos-
Autor(es): dc.creatorAbrantes, Christiane de Freitas-
Autor(es): dc.creatorVerly, Rodrigo Moreira-
Autor(es): dc.creatorResende, Jarbas Magalhães-
Autor(es): dc.creatorVeloso, Dorila Piló-
Autor(es): dc.creatorRezende, Simone Aparecida-
Autor(es): dc.creatorRomero, Oscar Bruna-
Autor(es): dc.creatorFernandes, Ana Paula-
Autor(es): dc.creatorGazzinelli, Ricardo Tostes-
Data de aceite: dc.date.accessioned2019-11-06T13:31:20Z-
Data de disponibilização: dc.date.available2019-11-06T13:31:20Z-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2014-11-20-
Data de envio: dc.date.issued2008-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4003-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557136-
Descrição: dc.descriptionA2was identified as an amastigote virulence factor of Leishmania (Leishmania) donovani and as a candidate antigen for vaccine development against visceral leishmaniasis. Here, predicted hydrophilic, class I and II MHC-binding synthetic peptides were used to define epitopes recognized by A2-specific antibodies, CD8+ T and CD4+ T cells, respectively. Immunization of BALB/c mice with adenovirus expressing A2 (AdA2) resulted in lowantibody response, contrasting with high levels of IFN-_ producing CD4+ T and CD8+ T cells specific for A2. Further, A2-specific CD8+ T cells from immunized mice were capable of lysing sensitized target cells in vivo. Finally, we demonstrated an association of A2-specific T cell responses and reduced parasitism in both liver and spleen from mice immunized with AdA2 and challenged with L. (L.) chagasi.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890061017.-
Palavras-chave: dc.subjectLeishmaniasis-
Palavras-chave: dc.subjectRecombinant vaccine-
Palavras-chave: dc.subjectEpitope mapping-
Título: dc.titleEpitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN- and cytolytic activity by CD8+ T cells.-
Aparece nas coleções:Repositório Institucional - UFOP

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