Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorFernandes, Ana Paula-
Autor(es): dc.creatorCoelho, Eduardo Antônio Ferraz-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorGrimaldi Junior, Gabriel-
Autor(es): dc.creatorGazzinelli, Ricardo Tostes-
Data de aceite: dc.date.accessioned2019-11-06T13:30:54Z-
Data de disponibilização: dc.date.available2019-11-06T13:30:54Z-
Data de envio: dc.date.issued2014-11-11-
Data de envio: dc.date.issued2014-11-11-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/3762-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/556959-
Descrição: dc.descriptionABSTRACT: Visceral leishmaniasis is a major health problem in Latina America, as well as the Mediterranean region of Europe and Asia. We aimed to develop a vaccine against visceral leishmaniasis targeting the intracellular amastigotes, which is the parasite stage that persists throughout infections with Leishmania parasites. With this in mind, we identified an amastigote specific antigen (A2) that contains an immunogenic epitope for CD4+ T helper (Th) cells and multiple repetitive units encoding CD8+ cytotoxic T lymphocyte (CTL) epitopes. Vaccine formulations containing the recombinant A2 associated with saponin, alum and IL-12 or expressed by attenuated adenovirus were shown to be protective in mice, dogs and nonhuman-primates. We are currently identifying novel amastigote specific immunogenic proteins that could be aggregated to A2 to further improve the level of vaccineinduced cell-mediated immunity and protection against visceral leishmaniasis.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Current Opinion in Microbiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3461450283724-
Palavras-chave: dc.subjectVisceral leishmaniasis-
Palavras-chave: dc.subjectVaccine-
Título: dc.titleMaking an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives.-
Aparece nas coleções:Repositório Institucional - UFOP

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