Nanotechnology applied to the treatment of malaria.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMagalhães, Nereide Stela Santos-
Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Data de aceite: dc.date.accessioned2019-11-06T13:30:48Z-
Data de disponibilização: dc.date.available2019-11-06T13:30:48Z-
Data de envio: dc.date.issued2014-11-14-
Data de envio: dc.date.issued2014-11-14-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/3866-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/556918-
Descrição: dc.descriptionDespite the fact that we live in an era of advanced technology and innovation, infectious diseases, like malaria, continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional malaria chemotherapy are the development of multiple drug resistance and the non-specific targeting to intracellular parasites, resulting in high dose requirements and subsequent intolerable toxicity. Nanosized carriers have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Several nanosized delivery systems have already proved their effectiveness in animal models for the treatment and prophylaxis of malaria. A number of strategies to deliver antimalarials using nanocarriers and the mechanisms that facilitate their targeting to Plasmodium spp.-infected cells are discussed in this review. Taking into account the peculiarities of malaria parasites, the focus is placed particularly on lipid-based (e.g., liposomes, solid lipid nanoparticles and nano and microemulsions) and polymer-based nanocarriers (nanocapsules and nanospheres). This review emphasizes the main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria.-
Idioma: dc.languageen-
Direitos: dc.rightsO periódico Advanced Drug Delivery Reviews concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença:3460320566734.-
Palavras-chave: dc.subjectMalaria-
Palavras-chave: dc.subjectNanocarriers-
Palavras-chave: dc.subjectLiposomes-
Palavras-chave: dc.subjectNanocapsules-
Palavras-chave: dc.subjectAntimalarials-
Título: dc.titleNanotechnology applied to the treatment of malaria.-
Aparece nas coleções:Repositório Institucional - UFOP

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